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c/cagrilintide·submitted 1 months ago by u/sulphur_burps_sue

stalled for 5 weeks at 2.5mg and I refuse to panic this time

Labbranch of 7 comments

Long-ish post, sorry. tl;dr at the bottom. I have been tracking cagrilintide against triglycerides for 29 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here. Caveats up front: one person, one…

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7 comments, started 1 months ago
u/rania_salinas44 points·1 months ago
this is why i still read c/reconstitution
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u/noor_ivaturi27 points·1 months ago

amylin receptor distribution is different from GLP-1

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u/bpc_scepticresearch peptides17 points·1 months ago

tendon and cagrilintide literature in rodents is interesting

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u/chidi_yilmaz13 points·1 months ago

tendon and cagrilintide literature in rodents is interesting

Yes, exactly this, and it is the bit that took me 61 weeks to accept.

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u/ferritin_low0 points·1 months ago

CagriSema ratios in trials are fixed, do not extrapolate self-mixing

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u/chidi_yilmaz1 point·1 months ago

Strongly agree. REDEFINE is phase 16, not final.

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u/helga_vermeulen1 point·1 months ago·edited

Small correction: the trial was 14 weeks, not 38. Does not change your point but people will quote it.

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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