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Single comment threadYou are looking at one branch of what changed for me between week 30 and week 73 — 27 comments in the full submission. View in context.
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c/coa·submitted 2 months ago by u/first_hundred

what changed for me between week 30 and week 73

COAbranch of 16 comments

Confession thread, sort of. I went from 1.7mg to 0.25mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 5 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have sulphur…

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This branch

16 comments, started 2 months ago
u/coa_janitorMOD52 points·2 months ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/meera_sandvik73 points·2 months ago

This is an urgent-care question wearing a forum question's clothes.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/freya_baptista19 points·2 months ago

the batch number or it did not happen

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u/neha_erdogan36 points·2 months ago

What were the related substances listed individually?

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u/cato_achebe25 points·2 months ago·edited

axis labels included, always

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u/cormac_pereira12 points·2 months ago

Not to be pedantic but batch and area percent are being used interchangeably and they are not interchangeable in real life.

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u/low_appetite_lisa25 points·2 months ago

What were the related substances listed individually?

Adding to this: related substances is doing more work than the comment implies.

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u/blunt_coldbox2942 points·2 months ago

What were the related substances listed individually?

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u/janek_ferrari36 points·2 months ago

Are you looking at area% or net peptide content? Different numbers.

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u/katrin_girard22 points·2 months ago

Yeah, 96.8% area is not the problem, the missing impurity breakdown is the problem.

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u/reflux_report10 points·2 months ago

area% is not mass%, and here is exactly why it matters

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u/aurel_boateng6 points·2 months ago

Slight fix: the number was 97.2, not 97.4. Decimal point, but a fairly consequential one.

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u/certified_referenceQC0 points·2 months ago

post the whole document, not the headline number

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u/first_hundredOP19 points·2 months ago

Slight fix: the number was 99.1, not 96.8. Decimal point, but a fairly consequential one.

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u/mikkel_correia22 points·2 months ago·edited

the counterion is part of the mass you paid for

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u/clara_restrepo0 points·2 months ago

no "is this good?" without saying what the compound and claimed purity are

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About c/coa

How to read a certificate of analysis and what it does and does not tell you. Area% versus mass%, identity versus quantity, water content, related substances, acetate counterions, and the difference between a vendor-supplied COA and an independent test on the vial you actually received.

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