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c/coa·posted 1 year ago by u/low_appetite_lisa

reading batch threads from 2024 and half of it aged badly

Lab Receipts ×6 Slow Clap ×1 Cold Box ×2

Confession thread, sort of.

I went from 5mg to 1.7mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 20 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.

So now I have injection-site soreness I did not need and a data point I cannot interpret. Two lessons in one.

Posting it in the hope that somebody at week 52 reads it before doing the same thing.

11,687 up / 1,467 down89% upvoted54 commentsid 1yvrf97 Sep 2024

54 comments

26 in this archive, depth 5

best — the order this archive was captured in

u/aleksi_eriksen1.6k points·1 year ago·edited

Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.

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u/yannick_haddad760 points·1 year ago

Yeah, 96.8% area is not the problem, the missing impurity breakdown is the problem.

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u/low_appetite_lisaOP-21 points·1 year ago

Asked BCH for the batch-specific COA and they sent it within six hours, full document, batch number, date, everything. That is the baseline.

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u/low_appetite_lisaOP1 point·1 year ago

The chromatogram trace is where the real information lives. The summary number is just a headline.

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u/janek_ferrari1 point·1 year ago

Asked BCH for the batch-specific COA and they sent it within six hours, full document, batch number, date, everything.

Yes, exactly this, and it is the bit that took me 72 weeks to accept.

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u/hugo_bergstrom1.4k points·1 year ago

Half-life is about 168 hours, so steady state lands around week 23–5. Practical consequence: what you feel in week 1 is not what that dose does.

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u/ahmed_rasmussen1.1k points·1 year ago

Half-life is about 168 hours, so steady state lands around week 23–5.

Adding to this: water content is doing more work than the comment implies.

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u/rania_okonkwo523 points·1 year ago

purity and net content are two different numbers, same vial

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u/low_appetite_lisaOP0 points·1 year ago

Water content was 3.8%, acetate was 6.2%, purity was 99%, but net peptide was only 90% of the label weight. Perfectly honest, just chemistry.

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[removed]1 point·1 year ago

[removed by moderator]

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u/santiago_szabo205 points·1 year ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/hassan_chowdhury723 points·1 year ago

purity and net content are two different numbers, same vial

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u/alcohol_aversion810 points·1 year ago

Half-life is about 168 hours, so steady state lands around week 23–5.

Disagree on that part. 98.7% and 99.3% on the same vial is normal.

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u/yara_antonsen428 points·1 year ago

You have restated the marketing copy. What is the actual substance here.

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u/zeynep_zielinski136 points·1 year ago

area% is not mass%, and here is exactly why it matters

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u/vito_chowdhury79 points·1 year ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/elodie_yilmaz771 points·1 year ago

Strongly agree. Mass% and area% are answering different questions on the same document.

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u/teodor_jansen1k points·1 year ago

Cosigning. The batch number is load-bearing information.

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u/nikhil_lindqvist638 points·1 year ago·edited
genuinely useful, thanks
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u/first_hundredMOD351 points·1 year ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/nikhil_lindqvist136 points·1 year ago

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

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u/teodor_jansen39 points·1 year ago

the related substances line is where the story is

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u/laila_yilmaz338 points·1 year ago

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

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u/janek_ferrari186 points·1 year ago

Slight fix: the number was 97.4, not 97.2. Decimal point, but a fairly consequential one.

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u/amara_halonen143 points·1 year ago

Not to be pedantic but batch and purity are being used interchangeably and they are not interchangeable in real life.

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u/receptor_bias_rick231 points·1 year ago

Slight fix: the number was 97.4, not 97.2.

Yes, exactly this, and it is the bit that took me 68 weeks to accept.

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About c/coa

How to read a certificate of analysis and what it does and does not tell you. Area% versus mass%, identity versus quantity, water content, related substances, acetate counterions, and the difference between a vendor-supplied COA and an independent test on the vial you actually received.

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