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c/coa·posted 2 years ago by u/halima_boateng

[Discussion] we are measuring COA at the wrong time and calling it noise

Discussion Receipts ×7 Cold Box ×2 Slow Clap ×3

area percent. That is the whole post, but I will justify it.

Everything else people worry about in c/sideeffects is downstream of it. Titration speed, reflux, the endless dose arguments — most of it resolves if you sort area percent out first, and almost nobody does.

I say this having got it wrong for 18 months. My ApoB was the thing that eventually made me pay attention, which is a stupid way to learn a lesson that was in the sidebar the whole time.

5,481 up / 529 down91% upvoted23 commentsid 18ldr86 Jun 2024

23 comments

20 in this archive, depth 5

best — the order this archive was captured in

u/aurel_boateng837 points·2 years ago

The evidence standard in c/vendorvetting gets called too strict about once a month, and every time, the thread ends with the complainant agreeing.

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u/tomas_lehtinen-36 points·2 years ago

Yeah, 96.8% area is not the problem, the missing impurity breakdown is the problem.

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u/aurel_boateng391 points·2 years ago

the related substances line is where the story is

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u/joaquin_ivaturi745 points·2 years ago

Batch number and date of analysis? Both are load-bearing.

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u/halima_boatengOP293 points·2 years ago

the method line is doing real work, not just window dressing

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u/elodie_yilmaz493 points·2 years ago

area% is not mass%, and here is exactly why it matters

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u/alcohol_aversion406 points·2 years ago·edited

Half-life is about 168 hours, so steady state lands around week 11–5. Practical consequence: what you feel in week 1 is not what that dose does.

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u/yannick_haddad308 points·2 years ago

the related substances line is where the story is

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u/nadia_kjaer104 points·2 years ago·edited

Respectfully this is a sample of one presented as a finding.

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[removed]72 points·2 years ago

[removed by moderator]

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u/teodor_jansen61 points·2 years ago

the batch number or it did not happen

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u/nabila_espinoza206 points·2 years ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/wanjiru_varga60 points·2 years ago

the method line is doing real work, not just window dressing

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u/halima_boatengOP22 points·2 years ago

Yeah, 96.8% area is not the problem, the missing impurity breakdown is the problem.

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u/emil_agyeman101 points·2 years ago

the counterion is part of the mass you paid for

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About c/coa

How to read a certificate of analysis and what it does and does not tell you. Area% versus mass%, identity versus quantity, water content, related substances, acetate counterions, and the difference between a vendor-supplied COA and an independent test on the vial you actually received.

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