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c/coa·submitted 11 months ago by u/cormac_pereira

why does nobody talk about certificate of analysis

Questionbranch of 7 comments

Trying to settle this properly because the thread from last year went in circles. The claim: certificate of analysis matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 13 months without either producing anything. What would actually settle it is 3 people…

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7 comments, started 11 months ago
u/tuva_aalto592 points·11 months ago

Half-life is about 168 hours, so steady state lands around week 20–5. Practical consequence: what you feel in week 1 is not what that dose does.

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u/karma_irrelevant-31 points·11 months ago

no "is this good?" without saying what the compound and claimed purity are

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u/amira_dumitru1 point·11 months ago

the method line is doing real work, not just window dressing

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u/cormac_pereiraOP1 point·11 months ago

Did they give you the chromatogram or just the summary line?

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u/amylin_amyamylin1 point·11 months ago·edited

area% is not mass%, and here is exactly why it matters

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u/teodor_lokken1 point·11 months ago

Yeah, 96.8% area is not the problem, the missing impurity breakdown is the problem.

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How to read a certificate of analysis and what it does and does not tell you. Area% versus mass%, identity versus quantity, water content, related substances, acetate counterions, and the difference between a vendor-supplied COA and an independent test on the vial you actually received.

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