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c/coa·submitted 2 years ago by u/camila_lindqvist

[Meta] proposal — a flair for COA posts

COAbranch of 15 comments

Something I noticed reading old threads that I have not seen said out loud. The advice on certificate of analysis in this community changed substantially around the start of last year, and nobody went back and updated the older posts. So depending on which thread the search engine hands you, you get two contradictory…

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15 comments, started 2 years ago
u/meera_sandvik340 points·2 years ago
nobody says this and everybody needs to hear it
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u/purity_pedantMOD177 points·2 years ago

Retitled to remove editorialising. Put the evidence in the body.

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u/bastian_moreau57 points·2 years ago

the related substances line is where the story is

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u/wanjiru_varga26 points·2 years ago

the related substances line is where the story is

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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[removed]18 points·2 years ago

[removed by moderator]

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u/step_therapy_s14 points·2 years ago

the batch number or it did not happen

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u/yannick_haddad206 points·2 years ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/tomas_lehtinen138 points·2 years ago

axis labels included, always

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u/priya_palacios129 points·2 years ago

post the whole document, not the headline number

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u/dead_space_doug36 points·2 years ago

I am going to push back on this slightly.

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u/kavya_verhoeven81 points·2 years ago

no "is this good?" without saying what the compound and claimed purity are

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u/aleksi_eriksen285 points·2 years ago

The chromatogram trace is where the real information lives. The summary number is just a headline.

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u/camila_lindqvistOP107 points·2 years ago

Yeah, 96.8% area is not the problem, the missing impurity breakdown is the problem.

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u/dario_boateng157 points·2 years ago

the counterion is part of the mass you paid for

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u/mikkel_correia108 points·2 years ago

Yeah, 96.8% area is not the problem, the missing impurity breakdown is the problem.

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About c/coa

How to read a certificate of analysis and what it does and does not tell you. Area% versus mass%, identity versus quantity, water content, related substances, acetate counterions, and the difference between a vendor-supplied COA and an independent test on the vial you actually received.

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Independent HPLC and mass spec. The number you get is the number they found.

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c/coa rules
  1. Post the full document. Cropped COAs that hide the batch number or date get removed.
  2. Redact your own name and order id, not the vendor's batch details.
  3. No "is this good?" without saying what the compound and claimed purity are.
  4. Independent community. Nobody here sells anything, and anyone who tries is banned.
  5. Not medical advice. Describe what you did; never prescribe to a stranger.
  6. Claims need evidence. Batch numbers, dated screenshots, independent test reports, or a citation.
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