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c/coa·posted 2 years ago by u/camila_lindqvist

switched from 0.25mg to 1.7mg and the nausea got better, not worse

Question Receipts ×1 Clean Column ×2

related substances. That is the whole post, but I will justify it.

Everything else people worry about in c/darkspot is downstream of it. Titration speed, reflux, the endless dose arguments — most of it resolves if you sort related substances out first, and almost nobody does.

I say this having got it wrong for 18 months. My fasting insulin was the thing that eventually made me pay attention, which is a stupid way to learn a lesson that was in the sidebar the whole time.

3,387 up / 1,014 down77% upvoted40 commentsid 2wcox417 Sep 2023

40 comments

21 in this archive, depth 5

best — the order this archive was captured in

u/tomas_lehtinen451 points·2 years ago·edited

post the whole document, not the headline number

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u/certified_referenceMOD281 points·2 years ago

Removed a chain here. The rule is one line long and it is not negotiable.

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u/cormac_pereira212 points·2 years ago

Tested the GLB raw material and a reseller vial side-by-side. Same purity claim, different impurity profiles. Handling matters.

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u/meera_sandvik48 points·2 years ago

This is the correct framing. The COA structure matters as much as the number.

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u/dario_vermeulen152 points·2 years ago

Yeah, 96.8% area is not the problem, the missing impurity breakdown is the problem.

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[removed]55 points·2 years ago

[removed by moderator]

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u/soren_nkemelu106 points·2 years ago

the method line is doing real work, not just window dressing

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u/clara_restrepo155 points·2 years ago

the method line is doing real work, not just window dressing

Yes, exactly this, and it is the bit that took me 3 weeks to accept.

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u/cato_achebe108 points·2 years ago

Are you looking at area% or net peptide content? Different numbers.

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u/alcohol_aversion67 points·2 years ago

the method line is doing real work, not just window dressing

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u/camila_lindqvist72 points·2 years ago

axis labels included, always

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u/elodie_yilmaz23 points·2 years ago

the method line is doing real work, not just window dressing

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u/ignacio_silva125 points·2 years ago

the counterion is part of the mass you paid for

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u/freya_baptista36 points·2 years ago

Not convinced. The evidence does not support that reading.

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u/chidi_demir75 points·2 years ago

Are you looking at area% or net peptide content? Different numbers.

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u/camila_lindqvistOP32 points·2 years ago

The chromatogram trace is where the real information lives. The summary number is just a headline.

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u/emil_agyeman52 points·2 years ago

Yeah, 96.8% area is not the problem, the missing impurity breakdown is the problem.

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u/santiago_szabo23 points·2 years ago·edited

Asked TFC for the batch-specific COA and they sent it within six hours, full document, batch number, date, everything. That is the baseline.

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u/zaid_balogun27 points·2 years ago

I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.

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u/step_therapy_s14 points·2 years ago

redact your own name, not the vendor's batch details

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u/coa_janitormod · c/coa19 points·2 years ago

area% is not mass%, and here is exactly why it matters

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About c/coa

How to read a certificate of analysis and what it does and does not tell you. Area% versus mass%, identity versus quantity, water content, related substances, acetate counterions, and the difference between a vendor-supplied COA and an independent test on the vial you actually received.

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Independent HPLC and mass spec. The number you get is the number they found.

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