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c/coldchain·submitted 5 months ago by u/transit_variance

[Lab] 7th independent test on QSC, and the trend is the interesting part

PSAbranch of 15 comments

Long-ish post, sorry. tl;dr at the bottom. I have been tracking stability against eGFR for 13 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here. Caveats up front: one person, one lab, one…

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15 comments, started 5 months ago
u/hugo_bergstrom30 points·5 months ago

time-at-temperature integral is the dose, not just peak temperature

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u/emil_marchand17 points·5 months ago

I am going to push back on this slightly.

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u/hugo_bergstrom11 points·5 months ago

lane reports need origin, destination, carrier, and actual transit days

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u/emil_marchand7 points·5 months ago

lane reports need origin, destination, carrier, and actual transit days

Yes, exactly this, and it is the bit that took me 27 weeks to accept.

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u/tomas_lokken9 points·5 months ago

lane reports need origin, destination, carrier, and actual transit days

Adding to this: stability is doing more work than the comment implies.

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u/emeka_delgado3 points·5 months ago

no tracking numbers, no full addresses, no label photos — instant removal

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u/nadia_kjaer20 points·5 months ago

lyophilised powder is far more forgiving than reconstituted solution

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u/creatine_and_cardio12 points·5 months ago

customs clearance often breaks the cold chain, factor that in

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u/fatima_yildiz3 points·5 months ago

lane reports need origin, destination, carrier, and actual transit days

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u/preservative_free_p4 points·5 months ago

a warm courier van is a bigger problem for a mixed vial than for dry powder

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u/tomas_lokken8 points·5 months ago

This is correct. Dry powder is way more robust than liquid.

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u/jarno_adeyemi6 points·5 months ago

excursion claims need a logger trace or a photo at unboxing, not "it felt warm"

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u/prior_auth_painappeals7 points·5 months ago

time-at-temperature integral is the dose, not just peak temperature

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u/honest_syringe332 points·5 months ago

gel packs last 19 hours, after that you are relying on the box itself

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u/transit_varianceOP23 points·5 months ago

Customs clearance took 24 days. Package sat unrefrigerated during that. Powder tested clean after, reconstituted solution probably would not have.

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About c/coldchain

Temperature and stability in the real world: what an excursion actually costs you, why lyophilised powder is far more forgiving than reconstituted solution, how to read a logger CSV, and how to photograph a failed shipment so the conversation with the vendor is short.

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