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c/compounding·posted 2 years ago by u/gallbladder_gary

[Discussion] we are measuring telehealth at the wrong time and calling it noise

Discussion Cold Box ×8

Posting this because I searched for it and got nothing useful.

Setup: 2.4mg, week 31, constipation present but not ruining anything. I changed exactly one variable — 503B — and tracked it for 13 weeks.

Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I am putting it here rather than presenting it as a finding. If two or three other people have done the same thing we might actually learn something.

Not medical advice, obviously. This is one person with a spreadsheet.

5,153 up / 4,564 down53% upvoted26 commentsid 1l74a421 Jul 2024

26 comments

22 in this archive, depth 5

best — the order this archive was captured in

u/gustav_cardoso52 points·2 years ago

Yeah, 503A and 503B are different regulatory animals.

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u/fatima_kowalski31 points·2 years ago
okay but what dose
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u/lukas_delgado8 points·2 years ago

Did they tell you their API source or dodge the question?

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u/rohan_steiner4 points·2 years ago

the 503A/503B distinction is load-bearing, do not blur it

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u/runa_grimaldi3 points·2 years ago

Strongly agree. API source transparency matters.

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u/gallbladder_garyOP-15 points·2 years ago

Asked 7 compounders about API source. One told me, one dodged, one said they cannot say. The answer is the signal.

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u/gallbladder_garyOP1 point·2 years ago

the 503A/503B distinction is load-bearing, do not blur it

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u/incretin_ivypharmacology25 points·2 years ago

state board rules differ, say which state

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u/discount_math_dm7 points·2 years ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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u/neha_krastev6 points·2 years ago

shortage list status is shortage list, check the actual list

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u/enzo_ferrari3 points·2 years ago

shortage list status is 503A, check the actual list

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u/tove_ogunleye3 points·2 years ago

503B compounding is different from 503A, different rules, different legality

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u/honest_syringe1 point·2 years ago

Yeah, 503A and 503B are different regulatory animals.

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u/helga_vermeulen1 point·2 years ago

503B compounding is different from 503A, different rules, different legality

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u/chidi_demir1 point·2 years ago

API source questions are on-topic and compounders dodging them is newsworthy

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u/helga_vermeulen16 points·2 years ago

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

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u/elise_ramos9 points·2 years ago

Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.

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u/prior_auth_painappeals9 points·2 years ago

This is correct. The shortage list does expire and the rules change.

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u/tobias_vukovic7 points·2 years ago·edited

Not to be pedantic but 503B and telehealth are being used interchangeably and they are not interchangeable in real life.

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[deleted]3 points·2 years ago

[deleted]

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u/hydration_hank3 points·2 years ago

the shortage list is temporary, it ends and compounding becomes illegal again

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u/helga_vermeulen1 point·2 years ago

503B compounding is different from 503A, different rules, different legality

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About c/compounding

Compounded GLP-1s as a supply route: the 503A/503B distinction, the shortage-list mechanics that made compounding legal and then didn't, state board rules, telehealth prescriber models, and what a compounding pharmacy will and will not tell you about its API source.

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