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c/compounding·posted 4 months ago by u/step_count_stan

[Question] 503A — what am I missing here

Question Cold Box ×9

Confession thread, sort of.

I went from 0.5mg to 12.5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 10 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.

So now I have sulphur burps I did not need and a data point I cannot interpret. Two lessons in one.

Posting it in the hope that somebody at week 18 reads it before doing the same thing.

672 up / 206 down77% upvoted32 commentsid lyxkmt31 Mar 2026

32 comments

23 in this archive, depth 4

best — the order this archive was captured in

u/maren_sorensen79 points·3 months ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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u/joaquin_trevino33 points·3 months ago

the 503A/503B distinction is load-bearing, do not blur it

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u/mateusz_adebayo46 points·3 months ago

regulatory claims need a citation to the actual rule, not interpretation

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u/lukas_delgado36 points·3 months ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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u/emeka_chowdhury13 points·3 months ago

Yeah, 503A and 503B are different regulatory animals.

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u/quiet_moderatorMOD27 points·3 months ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/rafael_ostergaard19 points·3 months ago

This is correct. The shortage list does expire and the rules change.

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u/ayesha_radich25 points·3 months ago

no pharmacy referral codes, naming is fine, recruiting is not

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u/priya_palacios10 points·3 months ago

Strongly agree. API source transparency matters.

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u/food_noise_gonemaintenance3 points·3 months ago

Strongly agree.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/receptor_bias_rick19 points·3 months ago
^ this
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u/solene_eriksen15 points·3 months ago·edited

no pharmacy referral codes, naming is fine, recruiting is not

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u/mikkel_correia6 points·3 months ago

Did they tell you their API source or dodge the question?

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u/neha_krastev5 points·3 months ago

503B compounding is different from 503A, different rules, different legality

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u/ahmed_fonseca3 points·3 months ago

the Poland situation is different from the US, different regulations

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u/burned_once_twice10 points·3 months ago

This is correct. The shortage list does expire and the rules change.

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u/step_count_stanOP5 points·3 months ago

The 503A pharmacy I used lost their shortage list eligibility. Same day, compounding became illegal. Rules are real.

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u/ffmi_watcher7 points·3 months ago

What is the actual shortage list status right now?

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u/liver_enzyme_liz2 points·3 months ago·edited

regulatory claims need a citation to the actual rule, not interpretation

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u/enzo_ferrari6 points·3 months ago

What is the actual shortage list status right now?

Disagree on that part. 95.1% and 96.2% on the same vial is normal.

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u/step_count_stanOP3 points·3 months ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/ffmi_watcher2 points·3 months ago

telehealth costs telehealth plus compounding markup, total varies

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About c/compounding

Compounded GLP-1s as a supply route: the 503A/503B distinction, the shortage-list mechanics that made compounding legal and then didn't, state board rules, telehealth prescriber models, and what a compounding pharmacy will and will not tell you about its API source.

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c/compounding rules
  1. Regulatory claims need a citation to the actual rule, notice or docket.
  2. No pharmacy referral codes. Naming a pharmacy is fine; recruiting for it is not.
  3. API source questions are on-topic and pharmacies dodging them is newsworthy.
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