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c/glp1science·submitted 1 year ago by u/bastian_ekstrom

tried half-life for 17 weeks. here is what happened.

Needs Sourcebranch of 12 comments

I have had 17 orders now and I keep a table, so here is the honest summary rather than a vibe. Material has been consistent. Communication has not. Shipping has varied by about 14 days on nominally the same lane, which matters more in summer than in February. The independent number came back 96.8% against a claimed…

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12 comments, started 1 year ago
u/analog_alphabet142 points·1 year ago

do not extrapolate rodent data to human dosing without saying so

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u/anders_kuusela78 points·1 year ago

receptor distribution matters, GLP-1 is not everywhere

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u/ferran_batista44 points·1 year ago

do not extrapolate rodent data to human dosing without saying so

Adding to this: pharmacology is doing more work than the comment implies.

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u/not_my_main_nm14 points·1 year ago

Which paper are you quoting?

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u/farid_kuipers83 points·1 year ago

This is correct. Rodent data is investigational, not predictive.

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u/nora_lundgren54 points·1 year ago

amylin is not GLP-1, posts conflating them get corrected

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u/piotr_grimaldi22 points·1 year ago

the half-life is mechanism, affects steady state timing

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u/ferran_dahlberg31 points·1 year ago·edited

amylin is not GLP-1, posts conflating them get corrected

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u/emil_agyeman23 points·1 year ago

Not to be pedantic but pharmacology and mechanism are being used interchangeably and they are not interchangeable in real life.

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u/bastian_ekstromOP22 points·1 year ago

Rodent, human, or in vitro?

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u/fatima_kowalski15 points·1 year ago

That is net peptide content, not purity. Different number, different meaning.

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