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c/glp1science·submitted 9 months ago by u/milan_mensah

[Results] 87 weeks, 25kg, and receptor was the hard part

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I have had 17 orders now and I keep a table, so here is the honest summary rather than a vibe. Material has been consistent. Communication has not. Shipping has varied by about 32 days on nominally the same lane, which matters more in summer than in February. The independent number came back 98.4% against a claimed…

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6 comments, started 9 months ago
u/sig_figs_sammod · analytical45 points·9 months ago

Titration speed is a side-effect dial far more than an efficacy dial.

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u/osman_eriksen-36 points·9 months ago

cite the paper: journal, year, first author, links optional

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u/nadia_bakker-41 points·9 months ago

gastric emptying is real and explains most early fatigue

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u/mod_ambulatoryadmin1 point·9 months ago

amylin is not GLP-1, posts conflating them get corrected

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u/fatima_kowalski1 point·9 months ago

rodent gastric emptying tells you what to investigate, not what to expect in humans

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u/kian_balogun31 points·9 months ago

glucagon-receptor contribution is mechanism for dual and triple agonism

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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