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502
c/glp1science·posted 10 months ago by u/ismael_chukwu

switched from 7.5mg to 15mg and the constipation got better, not worse

Explainer Well Actually ×1

Been lurking in c/researchpeptides for about 20 months and finally have something worth posting.

Short version: week 17, 1.0mg, and gastric emptying is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 39 threads, and the answers split roughly down the middle.

What I actually want to know is whether the people saying it does not matter have measured it, or whether it is just repeated confidently. Happy to be told I am overthinking this — I probably am — but I would rather overthink it now than at week 11.

513 up / 11 down98% upvoted15 commentsid wjewez16 Sep 2025

15 comments

6 in this archive, depth 3

best — the order this archive was captured in

u/hassan_ostergaard34 points·10 months ago

I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.

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u/flair_enthusiast26 points·10 months ago

This is correct. Rodent data is investigational, not predictive.

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u/anders_kuusela11 points·10 months ago

Strongly agree. Central appetite is real but people overstate it.

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u/runa_cabrera23 points·10 months ago

Yeah, the incretin mechanism is doing the work here.

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u/not_my_main_nm5 points·10 months ago

Yeah, the incretin mechanism is doing the work here.

Disagree on that part. 97.9% and 97.6% on the same vial is normal.

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u/gustav_vermeulen15 points·10 months ago·edited

Yeah, the incretin mechanism is doing the work here.

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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