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c/glp1science·posted 3 months ago by u/formulary_fighter

[Meta] proposal — a flair for gastric emptying posts

Needs Source

Trying to settle this properly because the thread from last year went in circles.

The claim: mechanism matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 17 months without either producing anything.

What would actually settle it is 19 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.

If you have data, post the data. If you have an opinion, flair it as an opinion.

804 up / 899 down47% upvoted15 commentsid wk36ik10 Apr 2026

15 comments

15 in this archive, depth 4

best — the order this archive was captured in

u/camila_lindqvist14 points·3 months ago

Titration speed is a side-effect dial far more than an efficacy dial.

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u/amara_dziedzic7 points·3 months ago

Respectfully this is a sample of one presented as a finding.

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u/vikram_mbeki3 points·3 months ago·edited

Respectfully this is a sample of one presented as a finding.

Adding to this: mechanism is doing more work than the comment implies.

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u/kavya_kravchenko2 points·3 months ago

gastric emptying is real and explains most early nausea

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[removed]1 point·3 months ago

[removed by moderator]

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u/ferran_batista1 point·3 months ago

amylin is not GLP-1, posts conflating them get corrected

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u/tomas_broberg1 point·3 months ago

Is that mechanism or speculation?

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u/piotr_grimaldi1 point·3 months ago

Slight fix: the number was 99.0, not 98.9. Decimal point, but a fairly consequential one.

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u/formulary_fighterOPappeals1 point·3 months ago

Which paper are you quoting?

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u/emil_agyeman7 points·3 months ago

Disagree. What you are describing is consistent with mechanism, not with what you concluded.

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u/sig_figs_samMOD3 points·3 months ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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u/isabela_nilsen5 points·3 months ago

rodent appetite tells you what to investigate, not what to expect in humans

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u/nadia_fonseca4 points·3 months ago

rodent appetite tells you what to investigate, not what to expect in humans

Disagree on that part. 95.1% and 97.6% on the same vial is normal.

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u/formulary_fighterOPappeals3 points·3 months ago

Strongly agree. Central appetite is real but people overstate it.

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u/not_my_main_nm1 point·3 months ago

glucagon-receptor contribution is incretin for dual and triple agonism

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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