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c/glp1science·submitted 10 months ago by u/aa_analysis_andy

[Discussion] can we stop arguing about mechanism until somebody posts a number

Discussionbranch of 8 comments

I have had 3 orders now and I keep a table, so here is the honest summary rather than a vibe. Material has been consistent. Communication has not. Shipping has varied by about 22 days on nominally the same lane, which matters more in summer than in February. The independent number came back 97.9% against a claimed…

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8 comments, started 10 months ago
u/employer_carveout-27 points·10 months ago

Which paper are you quoting?

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u/ferran_dahlberg1 point·10 months ago

do not extrapolate rodent data to human dosing without saying so

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u/osman_eriksen1 point·10 months ago

do not extrapolate rodent data to human dosing without saying so

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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[removed]1 point·10 months ago

[removed by moderator]

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u/dose_creep_dan1 point·10 months ago

gastric emptying is real and explains most early fatigue

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u/katrin_marchetti1 point·10 months ago

cite the paper: journal, year, first author, links optional

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u/rafael_ostergaard1 point·10 months ago

This is correct. Rodent data is investigational, not predictive.

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u/nadia_bakker1 point·10 months ago

Not convinced. The evidence does not support that reading.

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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