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c/glp1science·submitted 5 months ago by u/tomas_broberg

reading gastric emptying threads from 2024 and half of it aged badly

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Trying to settle this properly because the thread from last year went in circles. The claim: appetite matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 21 months without either producing anything. What would actually settle it is 35 people measuring the same…

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8 comments, started 5 months ago
u/gustav_vermeulen24 points·5 months ago

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

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u/tomas_brobergOP10 points·5 months ago

Receptor distribution explains why sulphur burps hits gastric emptying but not pharmacology.

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u/cato_batista29 points·5 months ago

do not extrapolate rodent data to human dosing without saying so

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u/emeka_chowdhury10 points·5 months ago

Which paper are you quoting?

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u/rafael_ostergaard8 points·5 months ago

the half-life is receptor, affects steady state timing

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u/anders_kuusela6 points·5 months ago

central appetite signalling is real but people overweight it

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u/georgi_chowdhury4 points·5 months ago

Rodent, human, or in vitro?

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u/bastian_eriksen3 points·5 months ago·edited

receptor distribution matters, GLP-1 is not everywhere

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