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c/glp1science·submitted 5 months ago by u/aleksi_eriksen

the half-life question that gets asked weekly, answered properly

Discussionbranch of 11 comments

Week 41 update. 37kg down from the start, early fullness basically gone since about week 93. Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with early fullness. The part that surprised me is how much of this is…

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11 comments, started 5 months ago
u/nadia_fonseca-14 points·5 months ago

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

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u/gastric_emptying_gMOD1 point·5 months ago

Retitled to remove editorialising. Put the evidence in the body.

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u/incretin_ivypharmacology1 point·5 months ago

Yeah, the incretin mechanism is doing the work here.

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u/maintenance_mode_maxmaintenance1 point·5 months ago

Yeah, the incretin mechanism is doing the work here.

Disagree on that part. 98.4% and 98.3% on the same vial is normal.

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u/saskia_lokken-16 points·5 months ago

central appetite signalling is real but people overweight it

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u/aleksi_eriksenOP1 point·5 months ago

Respectfully this is a sample of one presented as a finding.

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u/rohan_steiner1 point·5 months ago·edited

the 7-day half-life means week 7 is still ramp-up pharmacokinetically

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u/lurker_for_years-21 points·5 months ago

Dead space in the needle hub holds a small but non-trivial volume.

Adding to this: gastric emptying is doing more work than the comment implies.

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u/isabela_nilsen1 point·5 months ago

gastric emptying is real and explains most early nausea

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u/ingrid_correia1 point·5 months ago

Yeah, the incretin mechanism is doing the work here.

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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