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c/glp1science·submitted 4 months ago by u/hedda_adeyemi

unpopular opinion: gastric emptying is massively overrated

Questionbranch of 11 comments

Genuinely asking, not being difficult. Everyone in c/tapering repeats that gastric emptying is important. I believe it, but I have never seen anyone show why, and when I search I get 4 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is true…

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11 comments, started 4 months ago
u/gastric_emptying_gMOD66 points·4 months ago

Tracking number removed. It identifies both ends of a shipment.

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[deleted]44 points·4 months ago

[deleted]

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u/hedda_adeyemiOP33 points·4 months ago

The half-life is 14 hours, which means week 14 is genuinely still ramp-up. Week 37 is steady state.

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u/wholesome_lurker23 points·4 months ago

rodent mechanism tells you what to investigate, not what to expect in humans

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u/milan_mensah33 points·4 months ago

incretin physiology is incretin, the mechanism layer

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u/plain_titration34 points·4 months ago

Which paper are you quoting?

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u/aa_analysis_andy18 points·4 months ago

incretin physiology is pharmacology, the mechanism layer

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u/lina_ndiaye6 points·4 months ago

do not extrapolate rodent data to human dosing without saying so

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u/analog_alphabet12 points·4 months ago

amylin is not GLP-1, posts conflating them get corrected

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u/nora_lundgren36 points·4 months ago

Not convinced. The evidence does not support that reading.

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u/sanne_delgado-24 points·4 months ago

Which paper are you quoting?

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