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c/glp1science·submitted 5 months ago by u/mod_ambulatory

am I the only one who found half-life harder than the injections

Speculationbranch of 6 comments

Confession thread, sort of. I went from 15mg to 7.5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 11 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have sulphur…

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6 comments, started 5 months ago
u/anya_salgado40 points·5 months ago

Is that mechanism or speculation?

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u/trialwatch_theoMOD15 points·5 months ago

Tracking number removed. It identifies both ends of a shipment.

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u/mod_ambulatoryOPadmin29 points·5 months ago

The confident tone is doing a lot of work that the evidence is not.

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u/slow_logbook30 points·5 months ago

This is correct. Rodent data is investigational, not predictive.

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u/tomas_lundgren18 points·5 months ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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