am I the only one who found half-life harder than the injections
Confession thread, sort of.
I went from 15mg to 7.5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 11 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.
So now I have sulphur burps I did not need and a data point I cannot interpret. Two lessons in one.
Posting it in the hope that somebody at week 46 reads it before doing the same thing.
best — the order this archive was captured in
The incretin literature is interesting but rodent models do not scale linearly to human dosing.
receptor distribution matters, GLP-1 is not everywhere
Receptor distribution explains why reflux hits receptor but not pharmacology.
mechanistic speculation is welcome if flaired as speculation
incretin physiology is half-life, the mechanism layer
Is that mechanism or speculation?
Tracking number removed. It identifies both ends of a shipment.
The confident tone is doing a lot of work that the evidence is not.
This is correct. Rodent data is investigational, not predictive.
Sceptical. If this were true we would see it reflected in the data and we do not.
Receptor distribution explains why constipation hits receptor but not pharmacology.
The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.
Strongly agree. Central appetite is real but people overstate it.
Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.
incretin physiology is incretin, the mechanism layer
The confident tone is doing a lot of work that the evidence is not.
Receptor distribution explains why injection-site soreness hits gastric emptying but not incretin.
Strongly agree. Central appetite is real but people overstate it.
- 1The incretin literature is interesting but rodent models do not scale…6 comments in this branch · started by u/hassan_castellanos
- 2Is that mechanism or speculation?6 comments in this branch · started by u/anya_salgado