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am I the only one who found half-life harder than the injections
Confession thread, sort of. I went from 15mg to 7.5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 11 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have sulphur…
The incretin literature is interesting but rodent models do not scale linearly to human dosing.
receptor distribution matters, GLP-1 is not everywhere
Receptor distribution explains why reflux hits receptor but not pharmacology.
mechanistic speculation is welcome if flaired as speculation
incretin physiology is half-life, the mechanism layer