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c/glp1women·posted 2 months ago by u/careful_gradient

genuine question about insulin resistance that I am slightly embarrassed to ask

Results Receipts ×8

Right, the fertility question again, but with numbers this time.

I have 3 data points over 18 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.

The thing I would flag for anyone new: the effect I am describing showed up at week 22, not week 71. People give up long before the interesting part.

Interested in whether this matches other people's logs or whether I am an outlier.

609 up / 187 down76% upvoted32 commentsid 178ipv21 May 2026

32 comments

23 in this archive, depth 4

best — the order this archive was captured in

u/nnt_nate57 points·2 months ago

hormonal contraception interactions are speculative

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u/vitamin_d_void47 points·2 months ago

hormonal contraception interactions are speculative

Adding to this: fertility is doing more work than the comment implies.

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u/kian_solberg39 points·2 months ago

hormonal contraception interactions are speculative

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u/nayeli_iyer71 points·2 months ago·edited

Has anyone actually got this in writing, or is it forum lore at this point?

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u/ewan_zielinski49 points·2 months ago

Australia here. Waited 10 months on a list, gave up, went private, and the total cost was roughly what I expected.

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u/gentle_correctionMOD28 points·2 months ago

Retitled to remove editorialising. Put the evidence in the body.

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u/pavel_nkemelu22 points·2 months ago

Strongly agree. Cycle changes are documented.

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u/appeal_letter_al38 points·2 months ago

Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.

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u/ravi_bergstrom28 points·2 months ago

Strongly agree. Cycle changes are documented.

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u/kenji_demir13 points·2 months ago·edited

Came off after 2 weeks for financial reasons. Regained about a third over the following year. Back on now at a much lower dose.

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u/careful_gradientOP-3 points·2 months ago

Week 8 for me and the honest summary is: 6kg down, fatigue manageable, and I have thought about food maybe four times today.

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u/honest_syringe_20251 point·2 months ago

hair-loss on contraception is real

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u/neha_rahimi1 point·2 months ago

Strongly agree. Cycle changes are documented.

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u/careful_gradientOP1 point·2 months ago

no cycle-tracking data with identifying details

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u/careful_gradientOP16 points·2 months ago

Maintenance for 15 months now. Weight moves within about 3kg and the dose is a quarter of what it peaked at.

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[removed]12 points·2 months ago

[removed by moderator]

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u/mateusz_achebe0 points·2 months ago

Strongly agree. Cycle changes are documented.

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u/rasmus_petrescu19 points·2 months ago

Not to be pedantic but contraception and perimenopause are being used interchangeably and they are not interchangeable in real life.

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u/tired_ledger_ftw15 points·2 months ago

That is net peptide content, not purity. Different number, different meaning.

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u/viktor_laurent13 points·2 months ago

PCOS and insulin resistance

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u/mei_cardoso4 points·2 months ago

pregnancy and trying-to-conceive get clinician pointer, not community advice

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u/zeynep_weiss20 points·2 months ago

hair-loss on contraception is real

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u/aleksi_eriksen9 points·2 months ago

Every time this gets posted it hits the front page and every time someone has to re-explain it.

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About c/glp1women

The questions the trials under-powered: PCOS and insulin resistance, cycle changes, fertility signal and contraception interactions, perimenopause and menopause weight physiology, and the fact that the pregnancy answer is always "not while trying, talk to your clinician".

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