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c/glp1women·posted 4 days ago by u/vitamin_d_void

[PCOS] insulin resistance, cycles, and the thing that finally worked

PCOS The Quiet One ×8

Trying to settle this properly because the thread from last year went in circles.

The claim: cycle matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 14 months without either producing anything.

What would actually settle it is 21 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.

If you have data, post the data. If you have an opinion, flair it as an opinion.

1,323 up / 1,118 down54% upvoted16 commentsid 1tyly726 Jul 2026

16 comments

14 in this archive, depth 4

best — the order this archive was captured in

u/santiago_marchetti31 points·3 days ago

contraception interaction claims need citation

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u/elodie_yilmaz21 points·3 days ago

contraception interaction claims need citation

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/coa_forgery_watch11 points·3 days ago

hormonal contraception interactions are speculative

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u/vitamin_d_voidOP36 points·3 days ago

The thing nobody prepared me for was the quiet. Not the appetite, the quiet. The constant negotiation in my head about food just stopped.

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u/rina_sobczak28 points·3 days ago

The thing nobody prepared me for was the quiet.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/kian_solberg22 points·3 days ago·edited

hair-loss on cycle is real

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u/wholesome_lurkerMOD17 points·4 days ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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[removed]7 points·3 days ago

[removed by moderator]

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u/zaid_grimaldi10 points·3 days ago
i wish i had read this 20 months ago
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u/jonas_cardoso5 points·3 days ago

i wish i had read this 20 months ago

Disagree on that part. 98.1% and 96.2% on the same vial is normal.

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u/blunt_coldbox_20247 points·3 days ago

perimenopause and menopause weight physiology

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u/signe_villalobos2 points·2 days ago

You have restated the marketing copy. What is the actual substance here.

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u/ilias_steiner8 points·2 days ago

the trials mostly studied men, perimenopause skipped

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u/careful_gradient9 points·3 days ago

This is correct. PCOS is real.

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About c/glp1women

The questions the trials under-powered: PCOS and insulin resistance, cycle changes, fertility signal and contraception interactions, perimenopause and menopause weight physiology, and the fact that the pregnancy answer is always "not while trying, talk to your clinician".

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