peak at 4.2 min, nobody can tell me what it is, ideas
chromatogram. That is the whole post, but I will justify it. Everything else people worry about in c/dosinglogs is downstream of it. Titration speed, muscle cramps, the endless dose arguments — most of it resolves if you sort chromatogram out first, and almost nobody does. I say this having got it wrong for 21…
instrument quality is less important than analyst consistency
instrument quality is less important than analyst consistency
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
the gradient is doing the separation work, not the column alone
Ran the same vial on two columns, different purity, both right, different separation. Method matters more than equipment.
a round-robin on baseline integration would be genuinely useful
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This is the "correlation is mechanism" thing again. You changed three variables at once.
the gradient is doing the separation work, not the column alone