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c/reconstitution·posted 1 year ago by u/saskia_rahimi

week 61 check-in — 7kg down, reflux manageable, one thing confusing me

Explainer Well Actually ×3 Slow Clap ×2 Receipts ×1

Week 23 update. 34kg down from the start, reflux basically gone since about week 63.

Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with reflux.

The part that surprised me is how much of this is admin. Ordering, storing, logging, remembering. Nobody mentions that the hard bit is not the drug, it is the routine.

Happy to answer anything. Please do not ask me what dose you should be on.

5,766 up / 1,307 down82% upvoted50 commentsid 14nzne2 Jun 2025

50 comments

30 in this archive, depth 6

best — the order this archive was captured in

u/RetaAndRegret2896 points·1 year ago

Half-life is about 168 hours, so steady state lands around week 16–5. Practical consequence: what you feel in week 1 is not what that dose does.

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u/janek_ferrari217 points·1 year ago·edited

u-100 syringe, not u-40, or your math is off by factor of 3

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u/a1c_arcT2D318 points·1 year ago

Cosigning. The concentration on the vial in marker is load-bearing.

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u/viktor_kirchner697 points·1 year ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/arne_restrepo318 points·1 year ago

show your working or it is unhelpful

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u/spain_receta110 points·1 year ago

Did you write the concentration on the vial?

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u/saskia_rahimiOP289 points·1 year ago

Did you write the concentration on the vial?

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u/india_generic_g202 points·1 year ago

the concentration on the vial in marker is the most important step

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u/anjali_tamm94 points·1 year ago·edited

Are you using a u-100 or u-40 syringe? That changes everything.

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u/units_not_mgsyringe math74 points·1 year ago

20mg vial, 2mL water, concentration is 20/2 — write it on the vial afterwards

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[deleted]49 points·1 year ago

[deleted]

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u/bac_water_banditMOD470 points·1 year ago

Removed a chain here. The rule is one line long and it is not negotiable.

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u/saskia_rahimiOP371 points·1 year ago

Two vials, two different concentrations, forgot which was which, almost made a 17 times error. Now I label everything.

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u/ahmed_rasmussen260 points·1 year ago

swirl, do not shake, or you are courting oxidation

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u/britta_nakamura128 points·1 year ago

dosing errors come from people reconstituting two vials differently and forgetting which is which

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u/viktor_kirchner291 points·1 year ago

20mg vial, 2mL water, concentration is 20/2 — write it on the vial afterwards

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u/a1c_arcT2D138 points·1 year ago

the concentration on the vial in marker is the most important step

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u/rosa_mensah218 points·1 year ago

Not convinced. The evidence does not support that reading.

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u/india_generic_g205 points·1 year ago

Titration speed is a side-effect dial far more than an efficacy dial.

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u/kavya_radich63 points·1 year ago

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

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u/emeka_delgado-35 points·1 year ago

stopper coring on the 18th draw because you keep using the same entry point. rotate.

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u/spain_receta14 points·1 year ago

15mg vial, 1mL water, concentration is 15/1 — write it on the vial afterwards

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u/priya_weiss4 points·1 year ago

swirl, do not shake, or you are courting oxidation

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u/yusuf_nakamura140 points·1 year ago

Titration speed is a side-effect dial far more than an efficacy dial.

Yes, exactly this, and it is the bit that took me 28 weeks to accept.

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u/oskar_ibarra129 points·1 year ago

Reconstituted at 2mL when I meant 19mL. Caught it because the units looked wrong. Write the concentration.

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u/runa_cabrera82 points·1 year ago

dead space is real and the syringe matters

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u/elin_ferrari99 points·1 year ago·edited

I am going to push back on this slightly.

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u/bruno_dumitru72 points·1 year ago

Dead space ate 19 units on a low-volume draw. Tiny impact at 0.5mg, massive impact at 0.25mg.

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u/elodie_grimaldi53 points·1 year ago

dosing errors come from people reconstituting two vials differently and forgetting which is which

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u/escrow_evangelist15 points·1 year ago

20mg vial, 2mL water, concentration is 20/2 — write it on the vial afterwards

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About c/reconstitution

The arithmetic and the technique. Bacteriostatic versus sterile water, reconstitution volume as a concentration choice, converting mg/mL into insulin-syringe units, dead space, swirl-not-shake, stopper coring, and how long a reconstituted vial is actually good for. Math errors get corrected fast and politely.

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