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c/reconstitution·posted 2 years ago by u/arne_restrepo

the mg/mL thing finally clicked for me and I want to write it down

Discussion Receipts ×7 Long Haul ×2 Well Actually ×3

Confession thread, sort of.

I went from 1.7mg to 0.25mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 4 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.

So now I have constipation I did not need and a data point I cannot interpret. Two lessons in one.

Posting it in the hope that somebody at week 74 reads it before doing the same thing.

8,177 up / 706 down92% upvoted46 commentsid kbaixx13 Jun 2024

46 comments

18 in this archive, depth 4

best — the order this archive was captured in

u/tl_dr_tina1.4k points·2 years ago·edited

The single most useful thing I did was write the concentration on the vial. Stopped all the confusion after that.

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u/bruno_dumitru1.7k points·2 years ago

i am begging people to write down the concentration

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u/arne_restrepoOP986 points·2 years ago

Spent 24 weeks confused about concentration math until someone showed me the table. 15mg, 2mL, concentration is 15/2.

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u/quiet_reader_99343 points·2 years ago

the concentration on the vial in marker is the most important step

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u/nabila_espinoza-32 points·2 years ago
tl;dr for anyone scrolling: concentration
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u/bruno_dumitru653 points·2 years ago

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

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u/mateusz_achebe432 points·2 years ago

The evidence standard in c/vendorvetting gets called too strict about once a month, and every time, the thread ends with the complainant agreeing.

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u/honest_syringe_2025123 points·2 years ago·edited

Yeah, showing the arithmetic is the fastest way for someone to spot the error.

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u/saskia_rahimi215 points·2 years ago

the concentration on the vial in marker is the most important step

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u/swirl_dont_shakereconstitution257 points·2 years ago

You have restated the marketing copy. What is the actual substance here.

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u/arne_restrepoOP88 points·2 years ago

This is correct. 3mL versus 17mL is the common mistake.

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u/yusuf_achebe165 points·2 years ago

dead space is real and the syringe matters

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u/rasmus_mensah121 points·2 years ago

What was the vial size and how much bac water?

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u/andres_sorensen53 points·2 years ago

10mg vial, 2mL water, concentration is 10/2 — write it on the vial afterwards

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u/iman_falk12 points·2 years ago

10mg vial, 2mL water, concentration is 10/2 — write it on the vial afterwards

Yes, exactly this, and it is the bit that took me 59 weeks to accept.

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u/dexa_twice_yearlybody comp116 points·2 years ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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About c/reconstitution

The arithmetic and the technique. Bacteriostatic versus sterile water, reconstitution volume as a concentration choice, converting mg/mL into insulin-syringe units, dead space, swirl-not-shake, stopper coring, and how long a reconstituted vial is actually good for. Math errors get corrected fast and politely.

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