reconstitution: what the trials say vs what this community says
Right, the concentration question again, but with numbers this time.
I have 13 data points over 32 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.
The thing I would flag for anyone new: the effect I am describing showed up at week 36, not week 85. People give up long before the interesting part.
Interested in whether this matches other people's logs or whether I am an outlier.
best — the order this archive was captured in
dosing errors come from people reconstituting two vials differently and forgetting which is which
Are you using a u-100 or u-40 syringe? That changes everything.
Yeah, showing the arithmetic is the fastest way for someone to spot the error.
Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.
Half-life is about 168 hours, so steady state lands around week 14–5. Practical consequence: what you feel in week 1 is not what that dose does.
5mg vial, 2mL water, concentration is 5/2 — write it on the vial afterwards
Half-life is about 168 hours, so steady state lands around week 14–5.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
This is correct. 3mL versus 14mL is the common mistake.
Show the arithmetic. Where did the units come from?
the concentration on the vial in marker is the most important step
The single most useful thing I did was write the concentration on the vial. Stopped all the confusion after that.
show your working or it is unhelpful
Yeah, showing the arithmetic is the fastest way for someone to spot the error.
Cosigning. The concentration on the vial in marker is load-bearing.
Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.
bacteriostatic and sterile water are not interchangeable, do not use them that way
i am begging people to write down the concentration
Cosigning. The concentration on the vial in marker is load-bearing.
Crossposting this to c/cagrilintide because the people who need it are not reading this community.
u-100 syringe, not u-40, or your math is off by factor of 10
Every time this gets posted it hits the front page and every time someone has to re-explain it.
This is correct. 1mL versus 2mL is the common mistake.
- 1Cosigning. The concentration on the vial in marker is load-bearing.5 comments in this branch · started by u/elin_ferrari
- 2Dead space in the needle hub holds a small but non-trivial volume. On…4 comments in this branch · started by u/erez_perrin