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c/reconstitution·submitted 2 years ago by u/vial_math_vera

reconstitution: what the trials say vs what this community says

Discussionbranch of 4 comments

Right, the concentration question again, but with numbers this time. I have 13 data points over 32 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign. The thing I would flag for anyone new: the effect I am…

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4 comments, started 2 years ago
u/erez_perrin366 points·2 years ago

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

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u/hedda_adeyemi306 points·2 years ago·edited

Half-life is about 168 hours, so steady state lands around week 14–5. Practical consequence: what you feel in week 1 is not what that dose does.

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u/soren_zamora213 points·2 years ago

5mg vial, 2mL water, concentration is 5/2 — write it on the vial afterwards

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u/oskar_kaufmann74 points·2 years ago

Half-life is about 168 hours, so steady state lands around week 14–5.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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About c/reconstitution

The arithmetic and the technique. Bacteriostatic versus sterile water, reconstitution volume as a concentration choice, converting mg/mL into insulin-syringe units, dead space, swirl-not-shake, stopper coring, and how long a reconstituted vial is actually good for. Math errors get corrected fast and politely.

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