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c/reconstitution·posted 2 years ago by u/viktor_erdogan

the units question that gets asked weekly, answered properly

PSA Clean Column ×7 Well Actually ×3 Long Haul ×3

Trying to settle this properly because the thread from last year went in circles.

The claim: mg/mL matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 10 months without either producing anything.

What would actually settle it is 33 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.

If you have data, post the data. If you have an opinion, flair it as an opinion.

18,038 up / 987 down95% upvoted40 commentsid 1ifp4n10 Jan 2024

40 comments

21 in this archive, depth 6

best — the order this archive was captured in

u/quarter_dose_queenlow and slow0 points·2 years ago

What was the vial size and how much bac water?

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u/units_not_mgMOD1 point·2 years ago

Removed a chain here. The rule is one line long and it is not negotiable.

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u/viktor_erdoganOP1 point·2 years ago

swirl, do not shake, or you are courting oxidation

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u/signe_grimaldi1 point·2 years ago·edited

Small correction: the trial was 19 weeks, not 3. Does not change your point but people will quote it.

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u/anya_antonsen1 point·2 years ago

Yeah, showing the arithmetic is the fastest way for someone to spot the error.

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u/ruben_cabrera1 point·2 years ago

never post a calculation as advice without stating the concentration

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[deleted]1 point·2 years ago

[deleted]

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u/arto_falk1 point·2 years ago

Cosigning. The concentration on the vial in marker is load-bearing.

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u/priya_guerrero2.3k points·2 years ago

Crossposting this to c/semaglutide because the people who need it are not reading this community.

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u/emil_wojcik1.8k points·2 years ago

The single most useful thing I did was write the concentration on the vial. Stopped all the confusion after that.

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u/bac_water_banditreconstitution491 points·2 years ago

Show the arithmetic. Where did the units come from?

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u/vito_beaulieu719 points·2 years ago

bacteriostatic and sterile water are not interchangeable, do not use them that way

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u/marisol_frisk279 points·2 years ago

Small correction: the trial was 11 weeks, not 36. Does not change your point but people will quote it.

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u/erez_perrin144 points·2 years ago

dead space is real and the syringe matters

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u/anya_antonsen88 points·2 years ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/erez_perrin0 points·2 years ago

swirl, do not shake, or you are courting oxidation

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u/bac_water_banditreconstitution113 points·2 years ago·edited

Small correction: the trial was 11 weeks, not 36.

Yes, exactly this, and it is the bit that took me 42 weeks to accept.

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u/santiago_ndiaye563 points·2 years ago

Yeah, showing the arithmetic is the fastest way for someone to spot the error.

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u/viktor_erdoganOP205 points·2 years ago

Slight fix: the number was 99.0, not 98.9. Decimal point, but a fairly consequential one.

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u/ines_ekstrom1.4k points·2 years ago

Show the arithmetic. Where did the units come from?

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About c/reconstitution

The arithmetic and the technique. Bacteriostatic versus sterile water, reconstitution volume as a concentration choice, converting mg/mL into insulin-syringe units, dead space, swirl-not-shake, stopper coring, and how long a reconstituted vial is actually good for. Math errors get corrected fast and politely.

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