GLPHubglpresearchhub.com
Read-only archive. GLP Research Hub is a static community record — nothing here is for sale, no account is needed, and no vote you cast is counted. Why?
Archived. This submission is more than a year old. Votes and new comments are closed, and some of the advice in it may have been superseded — check the community wiki for the current version.
7.1k
c/reconstitution·posted 2 years ago by u/ilias_steiner

switched from 10mg to 7.5mg and the injection-site soreness got better, not worse

Discussion Long Haul ×3 Sourced ×1 Well Actually ×1

Confession thread, sort of.

I went from 15mg to 7.5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 19 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.

So now I have reflux I did not need and a data point I cannot interpret. Two lessons in one.

Posting it in the hope that somebody at week 81 reads it before doing the same thing.

7,395 up / 298 down96% upvoted37 commentsid flkfnd3 May 2024

37 comments

15 in this archive, depth 5

best — the order this archive was captured in

u/dexa_twice_yearlybody comp1.6k points·2 years ago
source?
replysharereportpermalink
u/kavya_radich863 points·2 years ago

Dead space ate 19 units on a low-volume draw. Tiny impact at 15mg, massive impact at 1.0mg.

replysharereportpermalink
u/units_not_mgMOD510 points·2 years ago·edited

Tracking number removed. It identifies both ends of a shipment.

replysharereportpermalink
u/arto_falk628 points·2 years ago

Half-life is about 168 hours, so steady state lands around week 17–5. Practical consequence: what you feel in week 1 is not what that dose does.

replysharereportpermalink
u/ledger_modmod · vetting511 points·2 years ago

The confident tone is doing a lot of work that the evidence is not.

replysharereportpermalink
u/oskar_ibarra350 points·2 years ago

dead space is real and the syringe matters

replysharereportpermalink
u/priya_guerrero98 points·2 years ago

Cosigning. The concentration on the vial in marker is load-bearing.

replysharereportpermalink
u/cardio_endpoint_c-37 points·2 years ago

What was the vial size and how much bac water?

replysharereportpermalink
u/ilias_steinerOP1 point·2 years ago

15mg vial, 2mL water, concentration is 15/2 — write it on the vial afterwards

replysharereportpermalink
u/kenji_kimani1 point·2 years ago

15mg vial, 2mL water, concentration is 15/2 — write it on the vial afterwards

Yes, exactly this, and it is the bit that took me 63 weeks to accept.

replysharereportpermalink
u/ilias_steiner1 point·2 years ago

dead space is real and the syringe matters

replysharereportpermalink
u/elodie_grimaldi1 point·2 years ago

Small correction: the trial was 2 weeks, not 31. Does not change your point but people will quote it.

replysharereportpermalink
u/dexa_twice_yearlybody comp1 point·2 years ago

more water means more units for the same dose, which means finer resolution

replysharereportpermalink
u/reflux_report1 point·2 years ago

more water means more units for the same dose, which means finer resolution

Adding to this: dead space is doing more work than the comment implies.

replysharereportpermalink
u/tomas_kimani1 point·2 years ago

Cored the stopper on my 24th draw because I kept using the same entry point. Rotate the puncture site.

replysharereportpermalink
Permalinked branches
Deep branches get their own page so a single reply chain can be linked and read on its own.
About c/reconstitution

The arithmetic and the technique. Bacteriostatic versus sterile water, reconstitution volume as a concentration choice, converting mg/mL into insulin-syringe units, dead space, swirl-not-shake, stopper coring, and how long a reconstituted vial is actually good for. Math errors get corrected fast and politely.

88kmembers
130submissions
Aug 2023created
submissions / month, last year
Sponsored

Sigma-Aldrich Standards

Certified reference materials for peptide identity and purity work.

sigmaaldrich.com
More in c/reconstitution
c/reconstitution rules
  1. Show your numbers. "How many units?" with no mg and no mL cannot be answered.
  2. Never post a calculation as advice without stating the concentration it assumes.
  3. No sterile-compounding-for-others discussion. Personal handling only.
  4. Independent community. Nobody here sells anything, and anyone who tries is banned.
  5. Not medical advice. Describe what you did; never prescribe to a stranger.
  6. Claims need evidence. Batch numbers, dated screenshots, independent test reports, or a citation.
  7. No referral links, discount codes or affiliate URLs. Permanent ban, no appeal.
  8. No contact handles, wallet addresses or tracking numbers — they identify people.
  9. Be recognisably decent. Disagree hard, insult nobody.
Full rules and how they are enforced →
Moderators
u/bac_water_banditu/vial_math_verau/units_not_mgu/swirl_dont_shake
Volunteers. Unpaid, unaffiliated, and reachable through modmail only.
Before you read on

Several compounds discussed on GLP Research Hub are sold for research use only and are not approved for human use anywhere. Nothing here is medical advice and none of it is written by your clinician. If a post reads like an instruction, treat it as a description of what one stranger did.

Full disclaimer →