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[Question] does needle dead space actually matter at 2.5mg doses

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Something I noticed reading old threads that I have not seen said out loud.

The advice on units in this community changed substantially around the start of last year, and nobody went back and updated the older posts. So depending on which thread the search engine hands you, you get two contradictory answers with the same confidence.

I have listed what I think the current consensus is below. Correct me — that is the point of posting it.

464 up / 98 down83% upvoted20 commentsid k1mqn525 Jul 2026

20 comments

11 in this archive, depth 3

best — the order this archive was captured in

u/tl_dr_tina50 points·3 days ago

Spent 19 weeks confused about concentration math until someone showed me the table. 5mg, 3mL, concentration is 5/3.

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u/ilias_cabrera-16 points·3 days ago

Spent 19 weeks confused about concentration math until someone showed me the table.

Adding to this: units is doing more work than the comment implies.

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u/sock_puppet_spotterOP1 point·3 days ago

never post a calculation as advice without stating the concentration

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u/units_not_mgMOD43 points·4 days ago

Retitled to remove editorialising. Put the evidence in the body.

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u/oskar_kaufmann34 points·4 days ago

Yeah, showing the arithmetic is the fastest way for someone to spot the error.

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u/adaeze_cabrera23 points·4 days ago·edited

Mechanistically the bit that matters is reconstitution. It explains most of the early profile and a decent chunk of the outcome.

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u/oskar_ibarra16 points·4 days ago

Show the arithmetic. Where did the units come from?

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u/mateusz_achebe19 points·3 days ago

Crossposting this to c/intlshipping because the people who need it are not reading this community.

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u/gradient_goblin12 points·3 days ago

show your working or it is unhelpful

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u/priya_guerrero6 points·3 days ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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u/emil_wojcik9 points·4 days ago

swirl, do not shake, or you are courting oxidation

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About c/reconstitution

The arithmetic and the technique. Bacteriostatic versus sterile water, reconstitution volume as a concentration choice, converting mg/mL into insulin-syringe units, dead space, swirl-not-shake, stopper coring, and how long a reconstituted vial is actually good for. Math errors get corrected fast and politely.

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