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c/semaglutide·posted 2 years ago by u/gustav_solberg

[Results] 72 weeks, 31kg, and Wegovy was the hard part

Results Long Haul ×2 Clean Column ×3 Receipts ×3

Long-ish post, sorry. tl;dr at the bottom.

I have been tracking semaglutide against triglycerides for 13 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.

Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.

tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.

8,219 up / 1,130 down88% upvoted43 commentsid 13j6yx4 Mar 2024

43 comments

30 in this archive, depth 4

best — the order this archive was captured in

u/camila_sandvik543 points·2 years ago

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

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u/rafael_ostergaard442 points·2 years ago

Titration speed is a side-effect dial far more than an efficacy dial.

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u/gradient_goblin320 points·2 years ago

Yeah, 42 weeks on 1.7mg, same pattern, same timing.

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u/leila_vasquez194 points·2 years ago

Sweden here. Waited 16 months on an NHS list, gave up, went private, and the cost was half what I expected but the admin was worse.

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u/georgi_haddad96 points·2 years ago

How long were you at 2.5mg before you moved up?

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u/gustav_solbergOP61 points·2 years ago·edited

How long were you at 2.5mg before you moved up?

Yes, exactly this, and it is the bit that took me 14 weeks to accept.

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[removed]71 points·2 years ago

[removed by moderator]

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u/ines_castellanos114 points·2 years ago

Small correction: the trial was 11 weeks, not 16. Does not change your point but people will quote it.

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u/marta_trevino91 points·2 years ago

titration speed is titration plus side effects, period

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u/camila_mensa171 points·2 years ago

Strongly agree. If it is not working at 2.4mg after 52 weeks, going up is not automatically the answer.

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u/gustav_solbergOP89 points·2 years ago

The thing nobody prepared me for was that the appetite does not come back for a long time after you stop.

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u/viktor_nkemelu0 points·2 years ago

week 27 and i am still not at maintenance, do not rush the ladder

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u/katrin_diallo1 point·2 years ago·edited

Is that purity or net peptide content? They are not the same number.

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u/gustav_solbergOP1 point·2 years ago

Lost 40kg and gained a genuinely irritating amount of interest in analytical chemistry. This site did that to me.

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u/rafael_ostergaard67 points·2 years ago

week 30 on the pen, 23kg down, this is the answer

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u/iman_falk126 points·2 years ago

week 24 and i am still not at maintenance, do not rush the ladder

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u/sofia_wikstrom39 points·2 years ago

Did you time the injection consistently each week or was it more ad hoc?

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u/gustav_solberg52 points·2 years ago

week 37 and i am still not at maintenance, do not rush the ladder

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u/prior_auth_painappeals85 points·2 years ago

How long were you at 10mg before you moved up?

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u/adnan_karlsen59 points·2 years ago

Not to be pedantic but 2.4mg and food noise are being used interchangeably and they are not interchangeable in real life.

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u/joaquin_stanescu29 points·2 years ago

Right, and the corollary is that stopping escalation does not reset your tolerance, it just pauses the clock.

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u/plain_titration-34 points·2 years ago

week 26 on the pen, 9kg down, this is the answer

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u/nadia_bakker88 points·2 years ago

okay but what dose of sema are you on

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u/lane_map_larrylogistics71 points·2 years ago·edited

titration speed is weekly dosing plus side effects, period

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u/careful_gradient_again40 points·2 years ago

Right, and the corollary is that stopping escalation does not reset your tolerance, it just pauses the clock.

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u/hugo_bergstrom21 points·2 years ago

Week 70 for me and the honest summary is: 14kg down, nausea manageable, and the quiet happened around week 16.

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u/nadia_bakker0 points·2 years ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/niels_lindqvist35 points·2 years ago

Hard agree. Week 83 me needed this. Week 34 me is nodding smugly.

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u/gradient_goblin8 points·2 years ago

the quiet is real. the food noise just stops.

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