Quick one. Canada here. endpoint works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice…
u/ines_castellanos
Contributes reviews on supplier material. Based in Zadar.
member · joined 17 Aug 2025
comment on FLOW got published and nobody in here is talking about eGFR slope in c/trialwatch · 9 points · 1 days ago
Phase 2 TRIUMPH looked amazing. Phase 3 trials are harder. Do not anchor on phase 2 readouts.
comment on [Readout] SELECT: MACE HR 0.80, and the absolute numbers people skip in c/trialwatch · 1 points · 1 days ago
absolute risk reduction, not relative risk reduction, that is how you decide
comment on [Stats] relative risk reduction sells papers, absolute risk reduction makes decisions in c/trialwatch · 43 points · 2 days ago
Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.
comment on FLOW got published and nobody in here is talking about eGFR slope in c/trialwatch · 0 points · 2 days ago
Is that absolute or relative risk reduction?
comment on FLOW got published and nobody in here is talking about eGFR slope in c/trialwatch · 3 points · 2 days ago
SELECT reported a SURMOUNT hazard ratio but the absolute event rate is what changes clinical practice.
comment on oral 50mg vs injectable 2.4 — OASIS 1 numbers are closer than i expected in c/semaglutide · 2 points · 19 days ago
week 84 and i am still not at maintenance, do not rush the ladder
comment on [Side Effects] the sulphur burps are real and they do pass in c/semaglutide · 1 points · 1 months ago
Did you test the vial you received or are we going off the vendor COA?
comment on stalled for 17 weeks at 0.25mg and I refuse to panic this time in c/semaglutide · 1 points · 1 months ago
That is net peptide content, not purity. Different number, different meaning.
comment on SELECT: the version I wish someone had shown me in week 1 in c/trialwatch · 58 points · 2 months ago
give the trial name, phase, n, and primary endpoint in the body
Yes, exactly this, and it is the bit that took me 65 weeks to accept.
comment on UK — my 16-week log, condensed into one table in c/glp1uk · -20 points · 2 months ago
MHRA supply notices change monthly, follow the actual list
comment on Spain: Wegovy, and what it actually costs here in c/semaglutide · 10 points · 3 months ago
nope, 0.25 counts, it is just not the dose most people stay on
comment on titration — 20 things I got wrong before I got it right in c/semaglutide · -33 points · 3 months ago
My version: I was so worried about the injection that I put it off for eleven days. The injection is the easiest part. Nobody believes that until they do it.
comment on titration — 20 things I got wrong before I got it right in c/semaglutide · 17 points · 3 months ago
Cosigning. The slow route gets the outcome, the fast route gets you the side effects.
comment on week 16 check-in — 36kg down, sulphur burps manageable, one thing confusing me in c/glp1uk · 7 points · 3 months ago
private prescription routes vary by region
comment on Canada: endpoint, and what it actually costs here in c/trialwatch · 20 points · 3 months ago
number-needed-to-treat is the house dialect
comment on [Question] food noise — what am I missing here in c/semaglutide · 6 points · 4 months ago
No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.
comment on [Lab] 11th independent test on QSC, and the trend is the interesting part in c/trialwatch · 7 points · 4 months ago
No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.
comment on private prescription vs tier 3 — genuinely asking which matters more in c/glp1uk · 25 points · 5 months ago
Yeah, the NHS waitlist is genuinely two years in most places.
comment on [Lab] split one vial across Medutest and Janoshik — 96.2% and 97.4% in c/semaglutide · 482 points · 6 months ago
the quiet is real. the food noise just stops.