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c/trialwatch·posted 4 days ago by u/heart_rate_bump

[Readout] SELECT: MACE HR 0.80, and the absolute numbers people skip

Readout

Right, the TRIUMPH question again, but with numbers this time.

I have 8 data points over 28 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.

The thing I would flag for anyone new: the effect I am describing showed up at week 89, not week 43. People give up long before the interesting part.

Interested in whether this matches other people's logs or whether I am an outlier.

152 up / 57 down73% upvoted14 commentsid pyx8y525 Jul 2026

14 comments

14 in this archive, depth 5

best — the order this archive was captured in

u/forest_plot_fionaMOD15 points·4 days ago

Tracking number removed. It identifies both ends of a shipment.

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u/nora_oyelaran12 points·3 days ago·edited

What was the dropout rate?

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u/paper_trail_paulavetting10 points·2 days ago

What was the dropout rate?

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u/heart_rate_bumpOP6 points·2 days ago

off-label use data is different from approved-indication data

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u/hub_opssite staff10 points·2 days ago

Strongly agree. Phase 2 is investigational, not conclusive.

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u/hamza_weiss6 points·3 days ago

This is correct. Discontinuation arms show the regain reality.

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u/trialwatch_theotrial nerd4 points·2 days ago

Phase 2 TRIUMPH looked amazing. Phase 3 trials are harder. Do not anchor on phase 2 readouts.

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u/heart_rate_bumpOP3 points·3 days ago

STEP 1 readout: 97.6% mean weight loss, absolute numbers matter. Spread around that mean is enormous.

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u/hugo_norgaard1 point·3 days ago

the discontinuation arms are the interesting part, not the STEP endpoints

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u/yara_bakken3 points·2 days ago

You have restated the marketing copy. What is the actual substance here.

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u/careful_gradient_again1 point·2 days ago

the relative risk reduction in headlines is not the whole story

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u/forest_plot_fionastats1 point·2 days ago

the relative risk reduction in headlines is not the whole story

Adding to this: hazard ratio is doing more work than the comment implies.

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u/ines_castellanos1 point·1 days ago

absolute risk reduction, not relative risk reduction, that is how you decide

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[deleted]1 point·1 days ago

[deleted]

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