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c/semaglutide·posted 26 days ago by u/coa_janitor

[Discussion] we talk about dose like it is a score and it is not

Discussion Slow Clap ×6

Week 26 update. 37kg down from the start, early fullness basically gone since about week 78.

Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with early fullness.

The part that surprised me is how much of this is admin. Ordering, storing, logging, remembering. Nobody mentions that the hard bit is not the drug, it is the routine.

Happy to answer anything. Please do not ask me what dose you should be on.

939 up / 156 down86% upvoted29 commentsid 1fzue13 Jul 2026

29 comments

23 in this archive, depth 4

best — the order this archive was captured in

u/lane_map_larrylogistics97 points·26 days ago
fair enough
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u/anya_salgado78 points·26 days ago

Right, and the corollary is that stopping escalation does not reset your tolerance, it just pauses the clock.

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u/quiet_moderatormod48 points·26 days ago

Are you on a pen or research vial? Because the trajectory is different.

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u/dead_space_doug26 points·26 days ago

stalled at 0.25mg, went up, and regretted it, the stall would have broken anyway

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u/rasmus_kimani49 points·25 days ago·edited

Right, and the corollary is that stopping escalation does not reset your tolerance, it just pauses the clock.

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u/ahmed_okafor58 points·25 days ago

Slight fix: the number was 97.6, not 98.9. Decimal point, but a fairly consequential one.

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u/coa_janitormod · c/coa33 points·25 days ago

The evidence standard in c/vendorvetting gets called too strict about once a month, and every time, the thread ends with the complainant agreeing.

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u/anya_antonsen25 points·26 days ago

Half-life is about 168 hours, so steady state lands around week 21–5. Practical consequence: what you feel in week 1 is not what that dose does.

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u/adaeze_brandt13 points·26 days ago

week 11 and i am still not at maintenance, do not rush the ladder

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u/rohan_steiner17 points·26 days ago

week 11 and i am still not at maintenance, do not rush the ladder

Yes, exactly this, and it is the bit that took me 57 weeks to accept.

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u/endpoint_creep7 points·26 days ago

Ozempic versus Wegovy versus research grade is the wrong argument, they are literally the same molecule

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u/alcohol_aversion7 points·26 days ago

nope, 0.25 counts, it is just not the dose most people stay on

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u/sofia_wikstrom-34 points·25 days ago

Half-life is about 168 hours, so steady state lands around week 8–5. Practical consequence: what you feel in week 1 is not what that dose does.

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u/gustav_solberg15 points·25 days ago

pens are overpriced, research vials are research grade, same molecule different price

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u/coa_janitorOPmod · c/coa10 points·24 days ago

Week 21 for me and the honest summary is: 14kg down, muscle cramps manageable, and the quiet happened around week 3.

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u/kaplan_meier_kim4 points·24 days ago

Ireland here. Waited 21 months on an NHS list, gave up, went private, and the cost was half what I expected but the admin was worse.

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u/zeynep_weiss7 points·25 days ago

How long were you at 2.5mg before you moved up?

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u/kavya_radich4 points·25 days ago

You have restated the marketing copy. What is the actual substance here.

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u/prior_auth_painappeals4 points·24 days ago

Strongly agree. If it is not working at 1.0mg after 78 weeks, going up is not automatically the answer.

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u/camila_mensa4 points·24 days ago

How long were you at 10mg before you moved up?

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u/iman_falk1 point·23 days ago

the quiet is real. the food noise just stops.

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u/source_or_silence1 point·24 days ago·edited

What colour is the pen? Wegovy and Ozempic use different formulations.

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u/coa_janitorOPmod · c/coa1 point·23 days ago

my A1c moved before the scale did and i nearly missed it

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