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c/semaglutide·posted 6 months ago by u/hassan_castellanos

does 2.4mg actually matter or is it forum lore at this point

Results Sourced ×9 The Quiet One ×2 Clean Column ×2

Trying to settle this properly because the thread from last year went in circles.

The claim: semaglutide matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 21 months without either producing anything.

What would actually settle it is 3 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.

If you have data, post the data. If you have an opinion, flair it as an opinion.

11,938 up / 4,122 down74% upvoted41 commentsid havgck14 Jan 2026

41 comments

20 in this archive, depth 5

best — the order this archive was captured in

u/marit_coelho1.5k points·6 months ago

My reflux was worst at 0.5mg and better at 0.25mg, which makes no sense and I have stopped trying to explain it.

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u/hassan_castellanosOP2.2k points·6 months ago

My reflux was worst at 0.5mg and better at 0.25mg, which makes no sense and I have stopped trying to explain it.

Yes, exactly this, and it is the bit that took me 79 weeks to accept.

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u/hassan_castellanosOP1.8k points·6 months ago

Week 73 for me and the honest summary is: 33kg down, constipation manageable, and the quiet happened around week 24.

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u/greta_perrin0 points·6 months ago

the 2.4mg dose is not the target, it is just what the pen goes up to

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u/vikram_mbeki1.4k points·6 months ago

pens are overpriced, research vials are research grade, same molecule different price

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u/vikram_ferreira383 points·6 months ago

my triglycerides moved before the scale did and i nearly missed it

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u/freya_baptista381 points·6 months ago

Right, and the corollary is that stopping escalation does not reset your tolerance, it just pauses the clock.

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u/adnan_karlsen636 points·6 months ago

Week 73 for me and the honest summary is: 33kg down, constipation manageable, and the quiet happened around week 24.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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[deleted]1.1k points·6 months ago

[deleted]

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u/ewan_tulloch1.6k points·6 months ago

Ozempic versus Wegovy versus research grade is the wrong argument, they are literally the same molecule

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u/stubborn_batchlist_only1.1k points·6 months ago

Not to be pedantic but Wegovy and weekly dosing are being used interchangeably and they are not interchangeable in real life.

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u/ffmi_watcher353 points·6 months ago·edited

the 2.4mg dose is not the target, it is just what the pen goes up to

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u/quiet_moderatormod1k points·6 months ago·edited

That is net peptide content, not purity. Different number, different meaning.

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u/endpoint_creep845 points·6 months ago

titration speed is titration plus side effects, period

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u/rina_bergstrom1.1k points·6 months ago

Hard agree. Week 5 me needed this. Week 51 me is nodding smugly.

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u/nausea_notesside effects275 points·6 months ago

Hard agree.

Disagree on that part. 97.9% and 97.6% on the same vial is normal.

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u/joaquin_stanescu213 points·6 months ago·edited

That is net peptide content, not purity. Different number, different meaning.

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u/adaeze_brandt72 points·6 months ago

my ferritin moved before the scale did and i nearly missed it

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u/ffmi_watcher-16 points·6 months ago

week 18 on the pen, 21kg down, this is the answer

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