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c/sideeffects·posted 4 months ago by u/insulin_syringe_ian

[PSA] fatigue is not what most of this community thinks it is

PSA Clean Column ×6 Receipts ×2 Long Haul ×1

Been lurking in c/t2dglp1 for about 5 months and finally have something worth posting.

Short version: week 12, 15mg, and fatigue is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 15 threads, and the answers split roughly down the middle.

What I actually want to know is whether the people saying it does not matter have measured it, or whether it is just repeated confidently. Happy to be told I am overthinking this — I probably am — but I would rather overthink it now than at week 6.

6,006 up / 608 down91% upvoted68 commentsid 19dtea15 Mar 2026

68 comments

30 in this archive, depth 5

best — the order this archive was captured in

u/long_post_larry433 points·4 months ago
batch number?
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u/gentle_correctionMOD351 points·4 months ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/salma_baptista219 points·4 months ago

How many weeks in are you? 21 weeks is noise, 9 weeks is a trend.

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u/plain_titration_2024273 points·4 months ago·edited

Yeah, the reflux hit on day 19 for me too, not day 1.

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u/constipation_clubside effects225 points·4 months ago

the muscle cramps passes. i promise. not medical advice.

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u/vendorinvestigate_vic108 points·4 months ago

the the food-noise thing passes. i promise. not medical advice.

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u/adaeze_batista266 points·4 months ago

Yeah, the constipation hit on day 11 for me too, not day 1.

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u/janoshik_junkieindependent tester89 points·4 months ago

IANAD and neither is anyone upvoting this

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u/zeynep_ndiaye156 points·4 months ago

My sulphur burps was worst at 0.5mg and better at 1.0mg, which makes no sense but it is real.

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u/insulin_syringe_ianOP103 points·4 months ago·edited

Went to A&E convinced it was pancreatitis. Lipase normal. It was gallstones. Get checked, do not post and wait.

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u/elin_lindqvist82 points·4 months ago·edited

the food-noise thing stops around week 3 for most people

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u/fatima_asante67 points·4 months ago

Has anything else changed? Sleep, food, protein, anything?

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u/isabela_nilsen144 points·4 months ago

The injection-site soreness passes. I kept a log and the timeline was the only useful thing. 24 weeks and it was basically gone.

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u/adaeze_brandt119 points·4 months ago

Yeah, the early fullness hit on day 9 for me too, not day 1.

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u/milan_villalobos94 points·4 months ago

Yeah, the constipation hit on day 4 for me too, not day 1.

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u/insulin_syringe_ianOP73 points·4 months ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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u/sofia_wikstrom0 points·4 months ago

Yeah, the constipation hit on day 21 for me too, not day 1.

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[removed]1 point·4 months ago

[removed by moderator]

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u/sofia_wikstrom-10 points·4 months ago

resting heart rate moved up 10 bpm and settled back down when I stopped escalating

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u/vendorinvestigate_vic1 point·4 months ago

nausea on day 2 is normal, nausea after week 41 is worth checking

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u/priya_weiss1 point·4 months ago

the food-noise thing stops around week 17 for most people

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u/vendorinvestigate_vic1 point·4 months ago

Strongly agree. Describe your dose, your week number, and your titration speed or nobody can help.

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u/vendorinvestigate_vic89 points·4 months ago

week 57 and the fatigue is finally getting better

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u/gentle_correctionnice about it62 points·4 months ago

ask your actual doctor, not us

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u/emil_barros69 points·4 months ago

This is correct. The injection-site soreness is horrible for three weeks and then just ends.

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u/tomas_lehtinen21 points·4 months ago

Strongly agree. Describe your dose, your week number, and your titration speed or nobody can help.

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u/step_therapy_s14 points·4 months ago

the food-noise thing stops around week 60 for most people

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u/priya_weiss31 points·4 months ago

resting heart rate moved up 8 bpm and settled back down when I stopped escalating

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About c/sideeffects

Side-effect experience and management, with a strong bias toward the ones that are common and boring (nausea, constipation, reflux, fatigue, sulphur burps) and a hard line on the ones that are not (severe abdominal pain, persistent vomiting, jaundice, vision changes). This community is not a substitute for urgent care and the mods will say so bluntly.

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