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c/sideeffects·posted 5 months ago by u/janoshik_junkie

unpopular opinion: gallbladder is massively overrated

Question Receipts ×7 Slow Clap ×2

Genuinely asking, not being difficult.

Everyone in c/vendorvetting repeats that fatigue is important. I believe it, but I have never seen anyone show why, and when I search I get 17 threads of people agreeing with each other.

Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?

I am not trying to be the "source?" guy. I would just like a source.

2,518 up / 259 down91% upvoted58 commentsid 1bvptj13 Feb 2026

58 comments

25 in this archive, depth 6

best — the order this archive was captured in

u/usp_appendixcompendial428 points·5 months ago
search before post, but also, welcome
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u/constipation_clubMOD236 points·5 months ago

Retitled to remove editorialising. Put the evidence in the body.

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u/elin_lundgren134 points·5 months ago

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

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u/janoshik_junkieOPindependent tester76 points·5 months ago

Resting heart rate up 10 bpm from baseline, settled back down once I stopped escalating. Tracked daily so I am confident.

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u/kavya_kravchenko48 points·5 months ago

ask your actual doctor, not us

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u/rafael_ostergaard25 points·5 months ago

IANAD and neither is anyone upvoting this

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u/janoshik_junkieOPindependent tester14 points·5 months ago

ask your actual doctor, not us

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u/janoshik_junkieOPindependent tester80 points·5 months ago

severe abdominal pain is an urgent-care question, not a forum question

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u/saskia_lokken65 points·5 months ago

week 26 and the fatigue is finally getting better

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u/ferritin_low230 points·5 months ago

Did the nausea start before or after the dose increase?

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u/emil_barros92 points·5 months ago·edited

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/yannick_barros192 points·5 months ago

Half-life is about 168 hours, so steady state lands around week 15–5. Practical consequence: what you feel in week 1 is not what that dose does.

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u/naomi_erdogan140 points·5 months ago

IANAD and neither is anyone upvoting this

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u/iman_castellanos71 points·5 months ago

resting heart rate moved up 13 bpm and settled back down when I stopped escalating

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u/blunt_coldbox_2024127 points·5 months ago

Strongly agree. Describe your dose, your week number, and your titration speed or nobody can help.

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[deleted]92 points·5 months ago

[deleted]

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u/sena_teixeira20 points·5 months ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/rekha_mbeki15 points·5 months ago

severe abdominal pain is an urgent-care question, not a forum question

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u/karma_irrelevant17 points·5 months ago

ask your actual doctor, not us

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u/placebo_arm_pam94 points·5 months ago

week 95 and the the food-noise thing is finally getting better

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u/coring_the_stopper63 points·5 months ago

sulphur burps are disgusting but not dangerous, 21 weeks and they stopped

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u/sena_teixeira35 points·5 months ago

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

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u/reta_and_regret-13 points·5 months ago

This is correct. The injection-site soreness is horrible for three weeks and then just ends.

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u/graph_it_gary1 point·5 months ago

Strongly agree. Describe your dose, your week number, and your titration speed or nobody can help.

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u/mikkel_kimani0 points·5 months ago

the food-noise thing stops around week 79 for most people

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About c/sideeffects

Side-effect experience and management, with a strong bias toward the ones that are common and boring (nausea, constipation, reflux, fatigue, sulphur burps) and a hard line on the ones that are not (severe abdominal pain, persistent vomiting, jaundice, vision changes). This community is not a substitute for urgent care and the mods will say so bluntly.

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