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c/sideeffects·posted 3 months ago by u/mass_spec_maggie

does gallbladder actually matter or is it forum lore at this point

Side Effects Clean Column ×2 Long Haul ×1 The Quiet One ×1

Right, the constipation question again, but with numbers this time.

I have 13 data points over 36 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.

The thing I would flag for anyone new: the effect I am describing showed up at week 71, not week 25. People give up long before the interesting part.

Interested in whether this matches other people's logs or whether I am an outlier.

3,070 up / 78 down98% upvoted44 commentsid 1cf71t12 Apr 2026

44 comments

30 in this archive, depth 5

best — the order this archive was captured in

u/nausea_notesMOD729 points·3 months ago

Tracking number removed. It identifies both ends of a shipment.

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u/laila_delgado173 points·3 months ago

Resting heart rate up 10 bpm from baseline, settled back down once I stopped escalating. Tracked daily so I am confident.

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u/britt_abubakar200 points·3 months ago

You have restated the marketing copy. What is the actual substance here.

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u/priya_weiss137 points·3 months ago·edited

nausea on day 2 is normal, nausea after week 41 is worth checking

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u/yannick_barros0 points·3 months ago

Yeah, the muscle cramps hit on day 18 for me too, not day 1.

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u/gentle_correctionnice about it1 point·3 months ago

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

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u/ferritin_low265 points·3 months ago

Yeah, the the food-noise thing hit on day 5 for me too, not day 1.

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u/mass_spec_maggieOPMS136 points·3 months ago

hair loss is real and usually reversible when you stabilize

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u/mass_spec_maggieOPMS0 points·3 months ago

resting heart rate moved up 11 bpm and settled back down when I stopped escalating

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u/step_therapy_s1 point·3 months ago

nausea on day 2 is normal, nausea after week 43 is worth checking

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u/mass_spec_maggieOPMS1 point·3 months ago

The nausea was genuinely awful for three weeks and then simply stopped. Week 51 me did not think I would make it to week 2.

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u/brigade_detector1 point·3 months ago

ask your actual doctor, not us

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u/usp_appendixcompendial186 points·3 months ago

I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.

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u/leila_silva129 points·3 months ago

Disagree. What you are describing is consistent with nausea, not with what you concluded.

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u/vendorinvestigate_vic57 points·3 months ago

week 56 and the injection-site soreness is finally getting better

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u/ayesha_radich0 points·3 months ago

Same experience. Week 50 and it simply stopped. I know that is not useful information but it is what happened.

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u/ferran_krastev38 points·3 months ago

Small correction: the trial was 17 weeks, not 16. Does not change your point but people will quote it.

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u/chidi_demir55 points·3 months ago

Small correction: the trial was 21 weeks, not 22. Does not change your point but people will quote it.

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u/rina_bergstrom123 points·3 months ago

Did the the food-noise thing start before or after the dose increase?

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u/sofia_wikstrom88 points·3 months ago

week 54 and the nausea is finally getting better

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u/adaeze_brandt25 points·3 months ago

nausea on day 2 is normal, nausea after week 25 is worth checking

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u/liv_okafor58 points·3 months ago

severe abdominal pain is an urgent-care question, not a forum question

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u/plain_titration_202472 points·3 months ago

the food-noise thing stops around week 65 for most people

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u/line_petrov111 points·3 months ago

Yeah, the nausea hit on day 19 for me too, not day 1.

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u/salma_baptista90 points·3 months ago·edited

severe abdominal pain is an urgent-care question, not a forum question

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u/fatima_asante-9 points·3 months ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/rania_diallo0 points·3 months ago

early fullness at 15mg is different from 2.5mg

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About c/sideeffects

Side-effect experience and management, with a strong bias toward the ones that are common and boring (nausea, constipation, reflux, fatigue, sulphur burps) and a hard line on the ones that are not (severe abdominal pain, persistent vomiting, jaundice, vision changes). This community is not a substitute for urgent care and the mods will say so bluntly.

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