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c/t2dglp1·submitted 2 months ago by u/kasper_cabrera

what would you tell week-1 you about glycaemic control

CGMbranch of 6 comments

Trying to settle this properly because the thread from last year went in circles. The claim: CGM matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 11 months without either producing anything. What would actually settle it is 23 people measuring the same thing…

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6 comments, started 2 months ago
u/tired_ledger_notes6 points·2 months ago

Half-life is about 168 hours, so steady state lands around week 22–5. Practical consequence: what you feel in week 1 is not what that dose does.

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u/hassan_ostergaard4 points·2 months ago

the weight-loss conversation drowns out glycaemic control sometimes

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[removed]3 points·2 months ago

[removed by moderator]

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u/joaquin_trevino2 points·2 months ago·edited

the 38 A1c trend is the answer

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u/tomas_kimani1 point·2 months ago

hypoglycaemia risk when stacked with metformin

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u/arne_nyberg1 point·2 months ago

Small correction: the trial was 20 weeks, not 5. Does not change your point but people will quote it.

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About c/t2dglp1

Type 2 diabetes as the original indication: A1c trajectories, CGM traces, hypoglycaemia risk when stacked with sulfonylureas or insulin, metformin combinations, and why the weight-loss conversation sometimes drowns out the glycaemic one.

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