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c/t2dglp1·posted 4 months ago by u/ice_pack_audit

[Discussion] the T2D advice in here is 16 years out of date

Discussion Clean Column ×1

Long-ish post, sorry. tl;dr at the bottom.

I have been tracking T2D against ApoB for 29 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.

Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.

tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.

537 up / 152 down78% upvoted19 commentsid xids207 Mar 2026

19 comments

19 in this archive, depth 4

best — the order this archive was captured in

u/gentle_correctionMOD37 points·4 months ago

Tracking number removed. It identifies both ends of a shipment.

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[deleted]25 points·4 months ago

[deleted]

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u/priya_weiss-3 points·4 months ago

hypoglycaemia risk when stacked with A1c

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u/swirl_dont_shakereconstitution20 points·4 months ago

Strongly agree. A1c matters as much as weight.

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u/bastian_eriksen10 points·4 months ago

Strongly agree.

Adding to this: glycaemic control is doing more work than the comment implies.

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u/ice_pack_auditOPcold chain14 points·4 months ago

Has anyone actually got this in writing, or is it forum lore at this point?

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u/ice_pack_auditOPcold chain6 points·4 months ago

Maintenance for 10 months now. Weight moves within about 3kg and the dose is a quarter of what it peaked at.

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u/amylin_amyamylin26 points·4 months ago

hypoglycaemia risk when stacked with A1c

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u/kaia_cabrera15 points·4 months ago

CGM traces tell a story, numbers alone do not

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u/hassan_ostergaard10 points·4 months ago

Yeah, glycaemic control is the original use.

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u/not_my_main_nm4 points·4 months ago

no medication-stopping advice, ever

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u/ice_pack_auditOPcold chain2 points·4 months ago

Strongly agree. A1c matters as much as weight.

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u/rui_only_ro12 points·4 months ago

post A1c with units and assay date

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u/joaquin_trevino9 points·4 months ago·edited

Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.

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u/tired_ledger_notes4 points·4 months ago

Three years on this site and the questions have not changed at all.

Adding to this: glycaemic control is doing more work than the comment implies.

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u/hugo_norgaard2 points·4 months ago

no medication-stopping advice, ever

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u/emil_okwuosa8 points·4 months ago

Strongly agree. A1c matters as much as weight.

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u/bianca_demir4 points·4 months ago·edited

Week 84 for me and the honest summary is: 15kg down, constipation manageable, and I have thought about food maybe four times today.

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u/kian_verhoeven2 points·4 months ago

Week 84 for me and the honest summary is: 15kg down, constipation manageable, and I have thought about food maybe four times today.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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Type 2 diabetes as the original indication: A1c trajectories, CGM traces, hypoglycaemia risk when stacked with sulfonylureas or insulin, metformin combinations, and why the weight-loss conversation sometimes drowns out the glycaemic one.

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