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c/t2dglp1·posted 5 months ago by u/bianca_dziedzic

small win: A1c stopped being a problem at week 50

Question Well Actually ×5

Posting this because I searched for it and got nothing useful.

Setup: 5mg, week 77, injection-site soreness present but not ruining anything. I changed exactly one variable — metformin — and tracked it for 5 weeks.

Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I am putting it here rather than presenting it as a finding. If two or three other people have done the same thing we might actually learn something.

Not medical advice, obviously. This is one person with a spreadsheet.

697 up / 108 down87% upvoted25 commentsid y2czfy12 Feb 2026

25 comments

17 in this archive, depth 3

best — the order this archive was captured in

u/swirl_dont_shakereconstitution42 points·5 months ago

hypoglycaemia risk when stacked with A1c

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u/hana_lehtinen9 points·5 months ago

the eGFR change is the signal

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u/arne_amankwah3 points·5 months ago

Strongly agree. A1c matters as much as weight.

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u/priya_weiss23 points·5 months ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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u/bianca_dziedzicOP33 points·5 months ago

post A1c with units and assay date

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u/adnan_karlsen13 points·5 months ago

Yeah, glycaemic control is the original use.

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u/laila_wikstrom4 points·5 months ago

Yeah, glycaemic control is the original use.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/cormac_danquah13 points·5 months ago·edited

Maintenance for 8 months now. Weight moves within about 3kg and the dose is a quarter of what it peaked at.

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u/bianca_dziedzicOP6 points·5 months ago

Came off after 5 weeks for financial reasons. Regained about a third over the following year. Back on now at a much lower dose.

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u/laila_wikstrom4 points·5 months ago

Maintenance for 8 months now.

Adding to this: metformin is doing more work than the comment implies.

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u/step_count_stan8 points·5 months ago

the triglycerides change is the signal

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u/nora_ramos6 points·5 months ago

The confident tone is doing a lot of work that the evidence is not.

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u/gustav_lindholm2 points·5 months ago

hypoglycaemia risk when stacked with A1c

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[deleted]5 points·5 months ago

[deleted]

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u/appeal_letter_al2 points·5 months ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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u/iman_castellanos6 points·5 months ago

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

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About c/t2dglp1

Type 2 diabetes as the original indication: A1c trajectories, CGM traces, hypoglycaemia risk when stacked with sulfonylureas or insulin, metformin combinations, and why the weight-loss conversation sometimes drowns out the glycaemic one.

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c/t2dglp1 rules
  1. Insulin and sulfonylurea interactions are a real hypo risk. Do not hand-wave them.
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