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c/t2dglp1·posted 9 months ago by u/source_or_silence

genuine question about A1c that I am slightly embarrassed to ask

Question The Quiet One ×7

Something I noticed reading old threads that I have not seen said out loud.

The advice on metformin in this community changed substantially around the start of last year, and nobody went back and updated the older posts. So depending on which thread the search engine hands you, you get two contradictory answers with the same confidence.

I have listed what I think the current consensus is below. Correct me — that is the point of posting it.

579 up / 182 down76% upvoted22 commentsid ym91bx29 Oct 2025

22 comments

21 in this archive, depth 5

best — the order this archive was captured in

u/lucia_balogun81 points·9 months ago

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

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u/fasting_insulin_f-9 points·9 months ago

Sweden here. Waited 19 months on a list, gave up, went private, and the total cost was roughly what I expected.

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u/ice_pack_auditcold chain60 points·9 months ago

Came off after 14 weeks for financial reasons. Regained about a third over the following year. Back on now at a much lower dose.

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u/nhs_waitlist_nUK27 points·9 months ago

Second this question. I have wondered about T2D for 22 months and never seen a straight answer.

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u/source_or_silenceOP10 points·9 months ago

This is correct. Hypo risk is real.

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u/hana_lehtinen3 points·9 months ago

the weight-loss conversation drowns out glycaemic control sometimes

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u/protein_first_pnutrition1 point·9 months ago

Strongly agree. A1c matters as much as weight.

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u/hana_lehtinen1 point·9 months ago

the weight-loss conversation drowns out glycaemic control sometimes

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u/hassan_ostergaard1 point·9 months ago

How many weeks between the two measurements?

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u/hassan_ostergaard4 points·9 months ago

type 2 is the indication, weight loss is the side effect

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u/tomas_kimani7 points·9 months ago

This is correct. Hypo risk is real.

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u/fasting_insulin_fMOD14 points·9 months ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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u/nils_ferreira19 points·9 months ago·edited

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

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u/source_or_silence5 points·9 months ago

the A1c change is the signal

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[removed]2 points·9 months ago

[removed by moderator]

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u/throwaway_918215 points·9 months ago

The evidence standard in c/vendorvetting gets called too strict about once a month, and every time, the thread ends with the complainant agreeing.

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u/ice_pack_auditcold chain6 points·9 months ago

This is correct. Hypo risk is real.

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u/marisol_moreau2 points·9 months ago

the 33 A1c trend is the answer

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u/bianca_dziedzic18 points·9 months ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/stubborn_batchlist_maybe14 points·9 months ago

Disagree. What you are describing is consistent with T2D, not with what you concluded.

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u/katrin_girard8 points·9 months ago

metformin combo is standard

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About c/t2dglp1

Type 2 diabetes as the original indication: A1c trajectories, CGM traces, hypoglycaemia risk when stacked with sulfonylureas or insulin, metformin combinations, and why the weight-loss conversation sometimes drowns out the glycaemic one.

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