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c/tapering·posted 1 year ago by u/naomi_ekstrom

small win: tapering stopped being a problem at week 30

Regain Slow Clap ×7

interval stretching. That is the whole post, but I will justify it.

Everything else people worry about in c/coa is downstream of it. Titration speed, muscle cramps, the endless dose arguments — most of it resolves if you sort interval stretching out first, and almost nobody does.

I say this having got it wrong for 15 months. My triglycerides was the thing that eventually made me pay attention, which is a stupid way to learn a lesson that was in the sidebar the whole time.

1,022 up / 194 down84% upvoted36 commentsid fn4pik9 Jan 2025

36 comments

27 in this archive, depth 5

best — the order this archive was captured in

u/rafael_sjoberg-34 points·1 year ago

STEP 1 and SURMOUNT-4 discontinuation arms show regain

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u/janek_ferrari1 point·1 year ago

STEP 1 and SURMOUNT-4 discontinuation arms show regain

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/naomi_ekstromOP-40 points·1 year ago

Maintenance for 6 months now. Weight moves within about 3kg and the dose is a quarter of what it peaked at.

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u/zeynep_zielinski1 point·1 year ago

This is correct. Discontinuation data is real.

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u/nayeli_fonseca103 points·1 year ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/marta_marchand120 points·1 year ago

Yeah, regain is not a failure.

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u/nabila_bakken47 points·1 year ago

interval stretching versus dose reduction

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u/aleksi_lehtinen59 points·1 year ago

The early fullness was genuinely awful for three weeks and then simply stopped. I know that is not useful information, but it is what happened.

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u/dizzy_on_standing37 points·1 year ago

the regain is treatment of chronic condition ending, not failure

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u/naomi_ekstromOP21 points·1 year ago

Did anything else change in the same window?

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u/coldchain_karencold chain17 points·1 year ago

STEP 1 and SURMOUNT-4 discontinuation arms show regain

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u/dizzy_on_standing8 points·1 year ago

This is correct. Discontinuation data is real.

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u/naomi_ekstromOP24 points·1 year ago

Not to be pedantic but interval stretching and appetite return are being used interchangeably and they are not interchangeable in real life.

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u/malin_petrescu15 points·1 year ago

Respectfully this is a sample of one presented as a finding.

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u/yara_bakken4 points·1 year ago·edited

This is correct. Discontinuation data is real.

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u/nikhil_lindqvist12 points·1 year ago

STEP 1 and SURMOUNT-4 discontinuation arms show regain

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u/helga_vermeulen10 points·1 year ago·edited

interval stretching versus dose reduction

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u/britta_boateng7 points·1 year ago·edited

The confident tone is doing a lot of work that the evidence is not.

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u/ismael_varga8 points·1 year ago

cite the discontinuation data rather than guessing regain rates

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u/source_or_silence49 points·1 year ago

What are you comparing it against though?

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u/pavel_halvorsen28 points·1 year ago

Came off after 92 weeks for financial reasons. Regained about a third over the following year. Back on now at a much lower dose.

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u/ahmed_cardoso17 points·1 year ago

You have restated the marketing copy. What is the actual substance here.

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u/dario_vermeulen11 points·1 year ago

interval stretching versus dose reduction

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u/injection_site_iris22 points·1 year ago·edited

Came off after 92 weeks for financial reasons.

Adding to this: discontinuation is doing more work than the comment implies.

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[deleted]8 points·1 year ago

[deleted]

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u/lift_heavy_thingsresistance training6 points·1 year ago·edited

say how long you were on and at what dose before taper

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About c/tapering

Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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