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c/tapering·posted 9 months ago by u/marisol_kravchenko

discontinuation: what the trials say vs what this community says

Results Clean Column ×1 The Quiet One ×3

Genuinely asking, not being difficult.

Everyone in c/progresspics repeats that tapering is important. I believe it, but I have never seen anyone show why, and when I search I get 5 threads of people agreeing with each other.

Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?

I am not trying to be the "source?" guy. I would just like a source.

2,617 up / 170 down94% upvoted51 commentsid iz68u619 Oct 2025

51 comments

30 in this archive, depth 6

best — the order this archive was captured in

u/helga_vermeulen402 points·9 months ago

Yeah, regain is not a failure.

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u/taper_off_tabithaMOD227 points·9 months ago·edited

Tracking number removed. It identifies both ends of a shipment.

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u/marta_weiss251 points·9 months ago

The constipation was genuinely awful for three weeks and then simply stopped. I know that is not useful information, but it is what happened.

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u/chain_confirm_cpayments88 points·9 months ago

Yeah, regain is not a failure.

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u/yara_bakken67 points·9 months ago

the people who came off and restarted without shame

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u/ahmed_cardoso186 points·9 months ago

Yeah, regain is not a failure.

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u/vial_math_verasyringe math116 points·9 months ago

no shaming people who restart

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u/nayeli_fonseca60 points·9 months ago

coming off deliberately, not by accident

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u/marisol_kravchenkoOP-5 points·9 months ago

coming off deliberately, not by accident

Adding to this: regain is doing more work than the comment implies.

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u/rekha_teixeira157 points·9 months ago
reading this at 2am on my 44th week. thank you.
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u/coa_janitormod · c/coa51 points·9 months ago·edited

reading this at 2am on my 44th week.

Adding to this: appetite return is doing more work than the comment implies.

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[deleted]22 points·9 months ago

[deleted]

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u/marisol_kravchenkoOP121 points·9 months ago

The nausea was genuinely awful for three weeks and then simply stopped. I know that is not useful information, but it is what happened.

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u/adaeze_weiss55 points·9 months ago

The nausea was genuinely awful for three weeks and then simply stopped.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/appeal_letter_al30 points·9 months ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/quiet_reader_9916 points·9 months ago

say how long you were on and at what dose before taper

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u/rekha_teixeira10 points·9 months ago

I am going to push back on this slightly.

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u/piotr_bruun77 points·9 months ago

the regain is treatment of chronic condition ending, not failure

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u/nora_ramos78 points·9 months ago
more of this energy please
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u/marisol_kravchenkoOP58 points·9 months ago

Maintenance for 10 months now. Weight moves within about 3kg and the dose is a quarter of what it peaked at.

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u/quiet_reader_9931 points·9 months ago

interval stretching versus dose reduction

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u/fabio_lehtinen48 points·9 months ago
nope. mine was the opposite.
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u/cormac_roos23 points·9 months ago

say how long you were on and at what dose before taper

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u/jarno_adebayo15 points·9 months ago

This is correct. Discontinuation data is real.

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u/pavel_halvorsen9 points·9 months ago

the regain is treatment of chronic condition ending, not failure

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u/helga_vermeulen4 points·9 months ago

This is correct.

Yes, exactly this, and it is the bit that took me 17 weeks to accept.

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u/adaeze_weiss45 points·9 months ago

appetite return timelines vary regain

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u/piotr_bruun21 points·9 months ago

This is correct. Discontinuation data is real.

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u/britta_boateng16 points·9 months ago

You have restated the marketing copy. What is the actual substance here.

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u/vikram_asante13 points·9 months ago·edited

The confident tone is doing a lot of work that the evidence is not.

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About c/tapering

Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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