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c/tapering·posted 1 year ago by u/vial_math_vera

anyone else notice discontinuation kicking in around week 29

Trial Data Clean Column ×5 Slow Clap ×1 Well Actually ×1

Right, the tapering question again, but with numbers this time.

I have 20 data points over 4 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.

The thing I would flag for anyone new: the effect I am describing showed up at week 27, not week 76. People give up long before the interesting part.

Interested in whether this matches other people's logs or whether I am an outlier.

6,233 up / 314 down95% upvoted70 commentsid ip0c598 Aug 2024

70 comments

30 in this archive, depth 6

best — the order this archive was captured in

u/maintenance_mode_maxMOD1.4k points·1 year ago

Tracking number removed. It identifies both ends of a shipment.

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u/rina_bergstrom1.1k points·1 year ago

What was the batch number and which service?

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u/arne_restrepo680 points·1 year ago

Tracking number removed.

Adding to this: discontinuation is doing more work than the comment implies.

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u/vikram_ferreira465 points·1 year ago

Slight fix: the number was 97.6, not 95.1. Decimal point, but a fairly consequential one.

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u/vial_math_veraOPsyringe math264 points·1 year ago

Second this question. I have wondered about interval stretching for 18 months and never seen a straight answer.

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u/vial_math_veraOPsyringe math-37 points·1 year ago

Maintenance for 13 months now. Weight moves within about 3kg and the dose is a quarter of what it peaked at.

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u/vial_math_veraOPsyringe math1 point·1 year ago

Came off after 43 weeks for financial reasons. Regained about a third over the following year. Back on now at a much lower dose.

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u/ines_boateng343 points·1 year ago

Which country? Half the answers in this thread only apply in Ireland.

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u/marta_weiss503 points·1 year ago

Which country?

Adding to this: regain is doing more work than the comment implies.

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u/malin_petrescu0 points·1 year ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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u/chain_confirm_cpayments577 points·1 year ago

Maintenance for 10 months now. Weight moves within about 3kg and the dose is a quarter of what it peaked at.

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u/arne_amankwah208 points·1 year ago

the people who came off and restarted without shame

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u/nora_ramos388 points·1 year ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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u/piotr_bruun449 points·1 year ago·edited

STEP 1 and SURMOUNT-4 discontinuation arms show regain

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u/taper_off_tabitha392 points·1 year ago

I am going to push back on this slightly.

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u/jarno_adebayo303 points·1 year ago

I am going to push back on this slightly.

Disagree on that part. 96.8% and 96.2% on the same vial is normal.

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u/ines_boateng189 points·1 year ago

Yeah, regain is not a failure.

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u/lane_watchermod · logistics204 points·1 year ago

Which country? Half the answers in this thread only apply in France.

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u/dario_stanescu135 points·1 year ago

the regain is treatment of chronic condition ending, not failure

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u/lift_heavy_thingsresistance training40 points·1 year ago·edited

Yeah, regain is not a failure.

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u/rina_bergstrom46 points·1 year ago·edited

regain on taper is expected, plan for it

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u/controversial_only27 points·1 year ago

regain on taper is expected, plan for it

Yes, exactly this, and it is the bit that took me 30 weeks to accept.

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u/coldchain_karencold chain8 points·1 year ago·edited

This is correct. Discontinuation data is real.

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u/border_paperwork172 points·1 year ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/priya_guerrero204 points·1 year ago

tapering instructions are not welcome here

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u/nayeli_fonseca107 points·1 year ago

tapering instructions are not welcome here

Disagree on that part. 96.8% and 96.2% on the same vial is normal.

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u/ilias_kaufmann98 points·1 year ago

the 16 week discontinuation arm is the data

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u/dario_vermeulen94 points·1 year ago

Yeah, regain is not a failure.

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u/elin_varga32 points·1 year ago

The the food-noise thing was genuinely awful for three weeks and then simply stopped. I know that is not useful information, but it is what happened.

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u/valeria_cardoso42 points·1 year ago

Strongly agree. The regain is expected.

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About c/tapering

Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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