Came off deliberately and slowly. Regain was 4kg, not 24. Method matters.
member · joined 24 Jan 2025
comment on walking through what SURMOUNT-4 actually showed about stopping, since it gets misquoted constantly in c/tapering · 98 points · 3 days ago
exactly why I wrote it, saw three threads this month alone treating it as if it settled the taper-speed question when it never asked that question
See SURMOUNT-4 cited a lot in tapering discussions, often slightly wrong, so here's my attempt at describing what the withdrawal arm actually showed rather than the…
comment on genuine question, what does "tapering" actually mean for a weekly injectable, there’s no pill to cut in half in c/tapering · 176 points · 3 days ago
no formal consensus that I'm aware of, and that's kind of the honest answer. mine was mg reduction over time with the interval kept fixed. I've seen others describe interval stretching instead (same dose, longer gaps) or both combined. There's no standardized taper protocol published for these drugs the way there is for, say, some psychiatric medications.
comment on [Discussion] should this community stop using the word "relapse" for regain at all in c/tapering · 98 points · 3 days ago
"regain" is the more neutral word already available and used constantly in this exact community, I think the fix might be as simple as just using that consistently instead of reaching for "relapse" out of habit.
comment on quit cold, regained fast, and I’m still working through how I feel about that in c/darkspot · 154 points · 4 days ago
the speed thing is real and matches the withdrawal-arm data pretty directly, this isn't a willpower failure, it's roughly what the trials show happens when the drug stops without a plan for it. that doesn't make it feel better in the moment but it's not a personal failing.
comment on [Lab] three BPC vials, three vendors, purity all over the place in c/bpc157 · 1 points · 4 days ago
No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.
comment on [Resolved] restarted after a year off, zero shame framing allowed in this post in c/darkspot · 58 points · 4 days ago
strongly agree, and this reframe (chronic management vs one-time fix) is honestly the single biggest mental shift that helped my own relationship with the whole process
comment on [Results] came off deliberately over four months, regained 4kg not 24 in c/tapering · 0 points · 4 days ago
comment on [Trial Data] what the STEP 4 and SURMOUNT-4 withdrawal arms actually showed in c/tapering · 1 points · 5 days ago
Half-life is about 168 hours, so steady state lands around week 18–5.
Adding to this: discontinuation is doing more work than the comment implies.
comment on [Trial Data] what the STEP 4 and SURMOUNT-4 withdrawal arms actually showed in c/tapering · 21 points · 5 days ago
This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.
comment on tapered slowly over four months instead of stopping cold, regain was 4kg not 24 in c/maintenancephase · 91 points · 5 days ago
appreciate you doing that percentage, "4kg" alone doesn't mean much without the denominator and I should've led with the ratio myself
comment on tapered slowly over four months instead of stopping cold, regain was 4kg not 24 in c/maintenancephase · 27 points · 6 days ago
working on writing that up properly as a separate post, will link when it's done
comment on tapered slowly over four months instead of stopping cold, regain was 4kg not 24 in c/maintenancephase · 62 points · 6 days ago
completely agree, I'm one data point on a question the trials haven't directly answered, trying to be careful not to oversell it as proven
Coming off deliberately after 22 months, worked with my prescriber on a gradual step-down over about four months rather than just stopping. One year post-taper:…
comment on GIP agonism explained like i am five, please in c/tirzepatide · 34 points · 10 days ago
Week 94 on Mounjaro and 15kg down. The appetite reduction feels different from sema in ways I do not have words for yet.
comment on [Long Term] found my lowest effective dose by going down, not up in c/maintenancephase · 218 points · 11 days ago
Flair changed to match the content. Read the sidebar before posting next time and we are square.
comment on [Regain] appetite came back over five weeks, here is the timeline in c/tapering · 14 points · 12 days ago
Tracking number removed. It identifies both ends of a shipment.
comment on [Discussion] we have no vocabulary for success that is not a number going down in c/maintenancephase · 132 points · 18 days ago
This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.
comment on [Question] does the vial concentration change how much dead space costs me in c/tirzepatide · 42 points · 27 days ago
Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.
comment on [Discussion] non-peptide is doing more work than we give it credit for in c/orforglipron · 3 points · 29 days ago
cite ATTAIN/ACHIEVE arms specifically
Certified reference materials for peptide identity and purity work.
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Reference