[Trial Data] what the STEP 4 and SURMOUNT-4 withdrawal arms actually showed
Confession thread, sort of.
I went from 15mg to 7.5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 3 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.
So now I have early fullness I did not need and a data point I cannot interpret. Two lessons in one.
Posting it in the hope that somebody at week 36 reads it before doing the same thing.
best — the order this archive was captured in
This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.
Half-life is about 168 hours, so steady state lands around week 9–5. Practical consequence: what you feel in week 1 is not what that dose does.
Which country? Half the answers in this thread only apply in Canada.
Yeah, regain is not a failure.
Week 91 for me and the honest summary is: 44kg down, reflux manageable, and I have thought about food maybe four times today.
coming off deliberately, not by accident
the UK here. Waited 9 months on a list, gave up, went private, and the total cost was roughly what I expected.
Second this question. I have wondered about interval stretching for 19 months and never seen a straight answer.
tapering instructions are not welcome here
tapering instructions are not welcome here
Disagree on that part. 98.1% and 99.3% on the same vial is normal.
the 13 week discontinuation arm is the data
STEP 1 and SURMOUNT-4 discontinuation arms show regain
Half-life is about 168 hours, so steady state lands around week 18–5. Practical consequence: what you feel in week 1 is not what that dose does.
interval stretching versus dose reduction
Half-life is about 168 hours, so steady state lands around week 18–5.
Adding to this: discontinuation is doing more work than the comment implies.
STEP 1 and SURMOUNT-4 discontinuation arms show regain
- 1Second this question. I have wondered about interval stretching for 19…7 comments in this branch · started by u/laila_delgado
- 2Half-life is about 168 hours, so steady state lands around week 18–5.…4 comments in this branch · started by u/cormac_roos