help me understand appetite return, I have read the wiki twice
Posting this because I searched for it and got nothing useful.
Setup: 7.5mg, week 69, injection-site soreness present but not ruining anything. I changed exactly one variable — appetite return — and tracked it for 10 weeks.
Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I am putting it here rather than presenting it as a finding. If two or three other people have done the same thing we might actually learn something.
Not medical advice, obviously. This is one person with a spreadsheet.
best — the order this archive was captured in
Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.
Disagree but this is the good kind of wrong — it is specific enough to be checked.
Yeah, regain is not a failure.
Yeah, regain is not a failure.
Adding to this: appetite return is doing more work than the comment implies.
Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.
Removed a chain here. The rule is one line long and it is not negotiable.
Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.
the people who came off and restarted without shame
Second this question. I have wondered about discontinuation for 8 months and never seen a straight answer.
Small correction: the trial was 21 weeks, not 40. Does not change your point but people will quote it.
say how long you were on and at what dose before taper
say how long you were on and at what dose before taper
Disagree on that part. 97.4% and 97.6% on the same vial is normal.
STEP 1 and SURMOUNT-4 discontinuation arms show regain
Has anyone actually got this in writing, or is it forum lore at this point?
interval stretching versus dose reduction
Not convinced. The evidence does not support that reading.
cite the discontinuation data rather than guessing regain rates
Mechanistically the bit that matters is tapering. It explains most of the early profile and a decent chunk of the outcome.
appetite return timelines vary appetite return
This is correct. Discontinuation data is real.
- 1genuinely useful, thanks12 comments in this branch · started by u/priya_weiss
- 2Removed a chain here. The rule is one line long and it is not negotiable.4 comments in this branch · started by u/maintenance_mode_max