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c/tapering·posted 7 months ago by u/adaeze_weiss

someone explain regain to me like I have not read a paper in years

Trial Data Receipts ×8 Long Haul ×3

Genuinely asking, not being difficult.

Everyone in c/bloodwork repeats that interval stretching is important. I believe it, but I have never seen anyone show why, and when I search I get 16 threads of people agreeing with each other.

Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?

I am not trying to be the "source?" guy. I would just like a source.

2,072 up / 367 down85% upvoted47 commentsid k34nm214 Dec 2025

47 comments

8 in this archive, depth 4

best — the order this archive was captured in

u/nora_ramos130 points·7 months ago

Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.

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u/taper_off_tabitha83 points·7 months ago

cite the discontinuation data rather than guessing regain rates

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u/marta_weiss23 points·7 months ago

Strongly agree. The regain is expected.

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u/janek_ferrari63 points·7 months ago

cite the discontinuation data rather than guessing regain rates

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/chain_confirm_cpayments17 points·7 months ago

no shaming people who restart

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u/coldchain_karencold chain115 points·7 months ago

interval stretching versus dose reduction

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u/careful_gradient26 points·7 months ago

interval stretching versus dose reduction

Adding to this: tapering is doing more work than the comment implies.

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u/andres_restrepo137 points·7 months ago

Yeah, regain is not a failure.

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About c/tapering

Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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